Context-specific regulation of extracellular vesicle biogenesis and cargo selection

AC Dixson, TR Dawson, D Di Vizio… - … Reviews Molecular Cell …, 2023 - nature.com
To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

Exosomes

DM Pegtel, SJ Gould - Annual review of biochemistry, 2019 - annualreviews.org
Exosomes are small, single-membrane, secreted organelles of∼ 30 to∼ 200 nm in
diameter that have the same topology as the cell and are enriched in selected proteins …

Quantitative proteomics identifies proteins enriched in large and small extracellular vesicles

A Lischnig, M Bergqvist, T Ochiya, C Lässer - Molecular & Cellular …, 2022 - ASBMB
There is a long-held consensus that several proteins are unique to small extracellular
vesicles (EVs), such as exosomes. However, recent studies have shown that several of …

Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy

X Li, AL Corbett, E Taatizadeh, N Tasnim, JP Little… - APL …, 2019 - pubs.aip.org
ABSTRACT Exosomes are small ($30–140 nm) lipid bilayer-enclosed particles of
endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most …

Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity

Y Gao, X Zheng, B Chang, Y Lin, X Huang, W Wang… - Cell Research, 2022 - nature.com
STING, an endoplasmic reticulum (ER) transmembrane protein, mediates innate immune
activation upon cGAMP stimulation and is degraded through autophagy. Here, we report that …

Dental enamel formation and implications for oral health and disease

RS Lacruz, S Habelitz, JT Wright… - Physiological …, 2017 - journals.physiology.org
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

Tetraspanins in extracellular vesicle formation and function

Z Andreu, M Yáñez-Mó - Frontiers in immunology, 2014 - frontiersin.org
Extracellular vesicles (EVs) represent a novel mechanism of intercellular communication as
vehicles for intercellular transfer of functional membrane and cytosolic proteins, lipids, and …

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

FJ Verweij, MP Bebelman, CR Jimenez… - Journal of Cell …, 2018 - rupress.org
Exosomes are small endosome-derived extracellular vesicles implicated in cell–cell
communication and are secreted by living cells when multivesicular bodies (MVBs) fuse with …

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

MF Baietti, Z Zhang, E Mortier, A Melchior… - Nature cell …, 2012 - nature.com
The biogenesis of exosomes, small secreted vesicles involved in signalling processes,
remains incompletely understood. Here, we report evidence that the syndecan heparan …