While various clinical applications especially in oncology are now in progress such as
diagnosis, prognosis, therapy monitoring, or patient follow-up, the determination of structural …

Tumor-related stroma plays an active role in tumor invasion and metastasis. The tumor–
stroma ratio (TSR) in the pathologic specimen has drawn increasing attention from the field …

Assessment of KRAS status is mandatory in patients with metastatic colorectal cancer
(mCRC) before applying targeted therapy. We describe here a blinded prospective study to …

The tumor-stroma ratio (TSR) has been reported as a strong, independent prognostic
parameter in colon cancer as well as in other epithelial cancer types, and may be …

Background An artificial intelligence method could accelerate the clinical implementation of
tumour-stroma ratio (TSR), which has prognostic relevance in colorectal cancer (CRC). We …

Background The intra-tumor stroma percentage in colon cancer (CC) patients has previously
been reported by our group as a strong independent prognostic parameter. Patients with a …

Abstract Development of a Q-PCR-based assay for the high-performance analysis of
circulating cell-free DNA (ccfDNA) requires good knowledge of its structure and size. In this …

Primary culture of the cancer cells from patients' tumors can provide crucial information of
individual tumors, yet the technology has not been optimized until now. We developed an …

The tumour microenvironment consists of a complex mixture of non‐neoplastic cells,
including fibroblasts, immune cells and endothelial cells embedded in the proteins of the …

Purpose: Circulating cell-free DNA (ccfDNA) is a valuable source of tumor material obtained
from a simple blood sampling that enables noninvasive analysis of the tumor genome. Our …