Animal models of drug relapse and craving: from drug priming-induced reinstatement to incubation of craving after voluntary abstinence
High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …
Homeostasis meets motivation in the battle to control food intake
Signals of energy homeostasis interact closely with neural circuits of motivation to control
food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior …
food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior …
Sex differences in the medial prefrontal cortical glutamate system
MC Knouse, AG McGrath, AU Deutschmann… - Biology of Sex …, 2022 - Springer
Background Dysregulation in the prefrontal cortex underlies a variety of psychiatric illnesses,
including substance use disorder, depression, and anxiety. Despite the established sex …
including substance use disorder, depression, and anxiety. Despite the established sex …
Repeated Cannabidiol treatment reduces cocaine intake and modulates neural proliferation and CB1R expression in the mouse hippocampus
MÁ Luján, A Castro-Zavala, L Alegre-Zurano… - …, 2018 - Elsevier
Cannabinoid derivatives have shown promising results for treating neuropsychiatric
disorders, including drug addiction. Recent studies on the therapeutic effects of Cannabidiol …
disorders, including drug addiction. Recent studies on the therapeutic effects of Cannabidiol …
Factors modulating the incubation of drug and non-drug craving and their clinical implications
It was suggested in 1986 that cue-induced cocaine craving increases progressively during
early abstinence and remains high during extended periods of time. Clinical evidence now …
early abstinence and remains high during extended periods of time. Clinical evidence now …
Multiple faces of BDNF in cocaine addiction
Brain-derived neurotrophic factor (BDNF) has been found to play roles in many types of
plasticity including drug addiction. Here, we focus on rodent studies over the past two …
plasticity including drug addiction. Here, we focus on rodent studies over the past two …
Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction
Learned associations between drugs and environment play an important role in addiction
and are thought to be encoded within specific patterns of sparsely distributed neurons called …
and are thought to be encoded within specific patterns of sparsely distributed neurons called …
Role of DNA methylation in the nucleus accumbens in incubation of cocaine craving
R Massart, R Barnea, Y Dikshtein… - Journal of …, 2015 - Soc Neuroscience
One of the major challenges of cocaine addiction is the high rate of relapse to drug use after
periods of withdrawal. During the first few weeks of withdrawal, cue-induced cocaine craving …
periods of withdrawal. During the first few weeks of withdrawal, cue-induced cocaine craving …
Dampened mesolimbic dopamine function and signaling by saturated but not monounsaturated dietary lipids
C Hryhorczuk, M Florea, D Rodaros, I Poirier… - …, 2016 - nature.com
Overconsumption of dietary fat is increasingly linked with motivational and emotional
impairments. Human and animal studies demonstrate associations between obesity and …
impairments. Human and animal studies demonstrate associations between obesity and …
Incubation of methamphetamine craving is associated with selective increases in expression of Bdnf and trkb, glutamate receptors, and epigenetic enzymes in cue …
Cue-induced methamphetamine seeking progressively increases after withdrawal
(incubation of methamphetamine craving), but the underlying mechanisms are largely …
(incubation of methamphetamine craving), but the underlying mechanisms are largely …