The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

The idea of central nervous system as one-man band favoring neurons is long gone. Now
we all are aware that neurons and neuroglia are team players and constant communication …

Since the first formal description of Parkinson disease (PD) two centuries ago, our
understanding of this common neurodegenerative disorder has expanded at all levels of …

Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They
contiguously tile the entire central nervous system (CNS) and exert many essential complex …

Background Inflammasome-induced neuroinflammation is a major pathogenic mechanism
underlying the degeneration of nigral dopaminergic neurons in Parkinson's disease (PD) …

Parkinson's disease is characterised by a slow and progressive degeneration of
dopaminergic neurons in the substantia nigra. Despite intensive research, the cause of the …

Parkinson's disease (PD) is the second most common neurodegenerative disease. PD
patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural …

The discovery of the central role played by the protein alpha-synuclein in Parkinson's
disease and other Lewy body brain disorders has had a great relevance in the …

ABSTRACT A growing body of evidence indicates that an inflammatory process in the
substantia nigra, characterized by activation of resident microglia, likely either initiates or …