Behavioural economic accounts of addiction conceptualize harmful drug use as an operant
reinforcer pathology, emphasizing that a drug is consumed because of overvaluation of …

Alcohol use has been causally linked to more than 200 disease and injury conditions, as
defined by three-digit ICD-10 codes. The understanding of how alcohol use is related to …

Craving is a core feature of substance use disorders. It is a strong predictor of substance use
and relapse and is linked to overeating, gambling, and other maladaptive behaviors …

Evidence suggests that spironolactone, a nonselective mineralocorticoid receptor (MR)
antagonist, modulates alcohol seeking and consumption. Therefore, spironolactone may …

Social reinforcement-based treatments are effective for many, but not all, people with
addictions to drugs. We recently developed an operant rat model that mimics features of one …

Ghrelin is a peptide that is produced by endocrine cells that are primarily localized in the
stomach. Ghrelin receptors (GHSR) are expressed in the brain and periphery. Preclinical …

Substance use problems impair social functioning, academic achievement, and
employability. Psychological, biological, social, and environmental factors can contribute to …

Rationale Although increasingly subject to criticism, the brain disease model of addiction
(BDMA) remains dominant within addiction science. Yet few advocates or critics of the …

Behavior genetics is a controversial science. For decades, scholars have sought to
understand the role of heredity in human behavior and life-course outcomes. Recently …

Addiction is a chronic relapsing disease with high morbidity and mortality. Treatments for
addiction include pharmacological and psychosocial interventions; however, currently …