Playing with evolution: In his Nobel lecture, George P. Smith reconstructs the story of the
phage-display idea as he personally experienced it. The development of this technique is a …

Prostate cancer (PCa) is heterogeneous, harboring phenotypically diverse cancer cell types.
PCa cell heterogeneity is caused by genomic instability that leads to the clonal competition …

Cancer is one of the leading causes of mortality worldwide; nearly 10 million people died
from it in 2020. The high mortality rate results from the lack of effective screening …

SOX2 and OCT4 are key regulators of embryonic stem cell pluripotency. They are
overexpressed in prostate cancers and have been associated with cancer stem cell (CSC) …

CD44v6, a splice variant of the cell surface glycoprotein CD44, acts as a co-receptor for c-
Met and is upregulated in tumors with high metastatic potential. Methods: We screened a …

Aberrations of the epidermal growth factor receptor (EGFR), for example, mutations and
overexpression, play pivotal roles in various cellular functions, such as proliferation …

Urological cancer refers to cancer in organs of the urinary system and the male reproductive
system. It mainly includes prostate cancer, bladder cancer, renal cancer, etc., seriously …

There is a growing need to develop tumor targeting agents for aggressive cancers.
Aggressive cancers frequently relapse and are resistant to various therapies. Cancer stem …

Cancer is one of the leading causes of death worldwide. During tumor development and
progression, extracellular matrix is being intensively re-organized. One of the most abundant …

Wenn die Antikörper allerdings mit einem großen Überschuss des EcoRI-Proteins
(unregelmäßig blaue Form) behandelt werden, bevor sie mit den Phagen gemischt werden …