Cellular senescence refers to a stress response aiming to preserve cellular and, therefore,
organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic …

Mitochondria are the source of cellular energy production and are present in different types
of cells. However, their function is especially important for the heart due to the high demands …

Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and
mitochondrial genomes have had to closely coordinate their activities, as each encode …

Abstract Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that
hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative …

Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the
accurate replication, transmission and preservation of its integrity throughout the life of the …

As mitochondrial oxidative damage contributes to a wide range of human diseases,
antioxidants designed to be accumulated by mitochondria in vivo have been developed. The …

Significance: Mitochondrial function is central to a wide range of biological processes in
health and disease and there is considerable interest in developing small molecules that are …

During heart transplantation, storage in cold preservation solution is thought to protect the
organ by slowing metabolism, providing osmotic support and minimizing ischaemia …

Telomerase is a ribonucleoprotein that counteracts telomere shortening and can immortalise
human cells. There is also evidence for a telomere-independent survival function of …

Parkinson's disease associated mutations in leucine rich repeat kinase 2 (LRRK2) impair
mitochondrial function and increase the vulnerability of induced pluripotent stem cell (iPSC) …