Pancreatic β-cell insulin secretion, which responds to various secretagogues and hormonal
regulations, is reviewed here, emphasizing the fundamental redox signaling by NADPH …

Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige
adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondrial …

Pancreatic-β-cell-specifying transcription factor Nkx6. 1, indispensable for embryonic
development of the pancreatic epithelium and commitment to β-cell lineage, directly controls …

Significance: Mitochondria determine glucose-stimulated insulin secretion (GSIS) in
pancreatic β-cells by elevating ATP synthesis. As the metabolic and redox hub, mitochondria …

Redox signaling from mitochondria (mt) to the cytosol and plasma membrane (PM) has been
scarcely reported, such as in the case of hypoxic cell adaptation or (2-oxo-) 2-keto …

Islet integrity plays a major role in maintaining glucose homeostasis and thus replenishment
of damaged islets by differentiation of resident endocrine progenitors into neo islets …