Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat
stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

Leptin is a hormone discovered almost 30 years ago with important implications in
metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the …

Adipokines dysregulation, the main reason for cognitive impairments (CI) induced by
diabetes, shows a sex-dependent pattern inherently and in response to exercise. This study …

Aims The present study aims to compare the responses between male and female C57BL/6
mice to multiple metabolic challenges to understand the importance of sex in the control of …

The intrauterine and early postnatal periods represent key developmental stages in which
an organism is highly susceptible to being permanently influenced by maternal factors and …

Gestational diabetes mellitus (GDM) is a serious complication of pregnancy and is defined
as a state of glucose intolerance that is first diagnosed and arises during gestation. Although …

Weight loss triggers important metabolic responses to conserve energy, especially via the
fall in leptin levels. Consequently, weight loss becomes increasingly difficult with weight …

Diabetes is a complex disease characterized by hyperglycemia, together with polyuria,
polydipsia, and polyphagia. While Type 1 diabetes mellitus (T1DM) results from genetic …