Putting the data before the algorithm in big data addressing personalized healthcare

EM Cahan, T Hernandez-Boussard… - NPJ Digital …, 2019 - nature.com
Technologies leveraging big data, including predictive algorithms and machine learning, are
playing an increasingly important role in the delivery of healthcare. However, evidence …

[HTML][HTML] Underlying genetic architecture of resistance to mastitis in dairy cattle: A systematic review and gene prioritization analysis of genome-wide association …

SG Narayana, E de Jong, FS Schenkel… - Journal of Dairy …, 2023 - Elsevier
Mastitis, the most frequent disease in dairy cattle. Resistance to mastitis is a complex,
polygenic trait controlled by several genes, each with small effects. Genome-wide …

Application of Bayesian genomic prediction methods to genome-wide association analyses

A Wolc, JCM Dekkers - Genetics Selection Evolution, 2022 - Springer
Background Bayesian genomic prediction methods were developed to simultaneously fit all
genotyped markers to a set of available phenotypes for prediction of breeding values for …

Disentangling clustering configuration intricacies for divergently selected chicken breeds

AB Vakhrameev, VG Narushin, TA Larkina… - Scientific Reports, 2023 - nature.com
Divergently selected chicken breeds are of great interest not only from an economic point of
view, but also in terms of sustaining diversity of the global poultry gene pool. In this regard, it …

Identification, deployment, and transferability of quantitative trait loci from genome-wide association studies in plants

M Mohammadi, A Xavier, T Beckett, S Beyer, L Chen… - Current Plant …, 2020 - Elsevier
Over the past decade, the use of genome-wide association studies (GWAS) in plant
breeding for discovery and validation of quantitative trait loci (QTL) has vastly increased …

Genome-wide association study for morphological, physiological, and productive traits in Coffea arabica using structural equation models

MM Suela, CF Azevedo, ACC Nascimento… - Tree Genetics & …, 2023 - Springer
Yield is one of the most important traits of arabica coffee. Plant breeders seek to maximize
yield directly or indirectly, using other related traits. The standard multi-trait genome-wide …

Structural equation modeling for investigating multi-trait genetic architecture of udder health in dairy cattle

S Pegolo, M Momen, G Morota, GJM Rosa, D Gianola… - Scientific reports, 2020 - nature.com
Mastitis is one of the most prevalent and costly diseases in dairy cattle. It results in changes
in milk composition and quality which are indicators of udder inflammation in absence of …

Large-scale genome-wide SNP analysis reveals the rugged (and ragged) landscape of global ancestry, phylogeny, and demographic history in chicken breeds

NV Dementieva, YS Shcherbakov… - Journal of Zhejiang …, 2024 - Springer
The worldwide chicken gene pool encompasses a remarkable, but shrinking, number of
divergently selected breeds of diverse origin. This study was a large-scale genome-wide …

[HTML][HTML] Gut microbiome mediates host genomic effects on phenotypes: a case study with fat deposition in pigs

F Tiezzi, J Fix, C Schwab, C Shull… - Computational and …, 2021 - Elsevier
A large number of studies have highlighted the importance of gut microbiome composition in
shaping fat deposition in mammals. Several studies have also highlighted how host genome …

Utilizing trait networks and structural equation models as tools to interpret multi-trait genome-wide association studies

M Momen, MT Campbell, H Walia, G Morota - Plant methods, 2019 - Springer
Background Plant breeders seek to develop cultivars with maximal agronomic value, which
is often assessed using numerous, often genetically correlated traits. As intervention on one …