Valvular heart disease is a major cause of morbidity and mortality worldwide. Surgical valve
repair or replacement has been the standard of care for patients with valvular heart disease …

The immune response of the host towards a decellularized scaffold is complex. Not only can
a number of immune cells influence this process, but also the characteristics, preparation …

Based on its multifactorial nature, successful treatment of diabetic wounds requires
combinatorial approach. In this regard, we hypothesized that engraftment of a …

Extracellular matrix-derived scaffolds provide an efficient platform for the generation of organ-
like structures. Successful development of testicular organoids (TOs) with the capability of …

Biomaterials are one of efficient treatment options for tissue defects in regenerative
medicine. Compared to synthetic materials which tend to induce chronic inflammatory …

Background Effective culture systems for attachment, migration, proliferation, and
differentiation of spermatogonial stem cells (SSCs) can be a promising therapeutic modality …

Efficient cell seeding and subsequent support from a substrate ensure optimal cell growth
and neotissue development during tissue engineering, including heart valve tissue …

Congenital heart disease (CHD) is the most predominant birth defect and can require
several invasive surgeries throughout childhood. The absence of materials with growth and …

Extracellular vesicles (EVs) are particles released from different cell types and represent key
components of paracrine secretion. Accumulating evidence supports the beneficial effects of …

Cell-based therapy and tissue engineering are promising substitutes for liver transplantation
to cure end-stage liver disorders. However, the limited sources for healthy and functional …