Mechanistic insights into the dual role of CCAR2/DBC1 in cancer
HJ Kim, SJ Moon, JH Kim - Experimental & Molecular Medicine, 2023 - nature.com
Cell cycle and apoptosis regulator 2 (CCAR2), also known as deleted in breast cancer 1
(DBC1), has been recently identified as a master regulator of transcriptional processes and …
(DBC1), has been recently identified as a master regulator of transcriptional processes and …
CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis
Abstract Cell Cycle and Apoptosis Regulator 1 (CCAR1) and Cell Cycle and Apoptosis
Regulator 2 (CCAR2) have emerged as key players in physiology and pathophysiology, with …
Regulator 2 (CCAR2) have emerged as key players in physiology and pathophysiology, with …
[HTML][HTML] CK2α/CSNK2A1 phosphorylates SIRT6 and is involved in the progression of breast carcinoma and predicts shorter survival of diagnosed patients
Recently, the roles of sirtuins (SIRTs) in tumorigenesis have been of interest to oncologists,
and protein kinase CK2 α1 (CSNK2A1) has been shown to be involved in tumorigenesis by …
and protein kinase CK2 α1 (CSNK2A1) has been shown to be involved in tumorigenesis by …
Targeting the KIF4A/AR axis to reverse endocrine therapy resistance in castration-resistant prostate cancer
Q Cao, Z Song, H Ruan, C Wang, X Yang, L Bao… - Clinical Cancer …, 2020 - AACR
Purpose: Emerging evidence indicates that castration-resistant prostate cancer (CRPC) is
often driven by constitutively active androgen receptor (AR) or its V7 splice variant (AR-V7) …
often driven by constitutively active androgen receptor (AR) or its V7 splice variant (AR-V7) …
TRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway
Recent studies have shown that some members of the tripartite motif-containing protein
(TRIM) family serve as important regulators of tumorigenesis. However, the biological role of …
(TRIM) family serve as important regulators of tumorigenesis. However, the biological role of …
Methylation recognition protein YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) regulates the proliferation, migration and invasion of osteosarcoma by …
K Wei, Y Gao, B Wang, YX Qu - Bioengineered, 2022 - Taylor & Francis
ABSTRACT N6-methyladenosine (m6A) is one of the most significant modifications in
human mRNAs. Emerging evidence indicates that m6A participates in the initiation and …
human mRNAs. Emerging evidence indicates that m6A participates in the initiation and …
FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC
Recently, the roles of FAM83H in tumorigenesis have been interested and increased
expression of FAM83H and MYC in hepatocellular carcinoma (HCC) have been reported …
expression of FAM83H and MYC in hepatocellular carcinoma (HCC) have been reported …
Characteristics and prognostic factors of patients with osteosarcoma older than 60 years from the SEER database
Y Pan, D Chen, T Hu, G Lv, Z Dai - Cancer Control, 2019 - journals.sagepub.com
Osteosarcoma is predominant in the adolescent and the elderly population, but few studies
have described the characteristics and prognostic factors of patients older than 60 years. In …
have described the characteristics and prognostic factors of patients older than 60 years. In …
DBC1 promotes castration-resistant prostate cancer by positively regulating DNA binding and stability of AR-V7
SJ Moon, BC Jeong, HJ Kim, JE Lim, GY Kwon, JH Kim - Oncogene, 2018 - nature.com
Constitutively active AR-V7, one of the major androgen receptor (AR) splice variants lacking
the ligand-binding domain, plays a key role in the development of castration-resistant …
the ligand-binding domain, plays a key role in the development of castration-resistant …
FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas
Background FAM83H was initially identified as a protein essential for dental enamel
formation. Recent reports have shown that FAM83H is also involved in the progression of …
formation. Recent reports have shown that FAM83H is also involved in the progression of …