Loss of the Y chromosome (LOY) is observed in multiple cancer types, including 10–40% of
bladder cancers,,,,–, but its clinical and biological significance is unknown. Here, using …

Sex differences are present across multiple non-reproductive organ cancers, with male
individuals generally experiencing higher incidence of cancer with poorer outcomes …

Simple Summary Aberrations in epigenetic modulators have been widely identified in
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …

Oncogenic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 occur in a wide range
of cancers, including acute myeloid leukemia (AML) and glioma. Mutant IDH enzymes …

Background Mosaic loss of Y chromosome (LOY) is the most common chromosomal
alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that …

Heart failure affects millions of people worldwide, with men exhibiting a higher incidence
than women. Our previous work has shown that mosaic loss of the Y chromosome (LOY) in …

Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal
alterations (mCAs) of the autosomes, X, and Y chromosomes are aging-related somatic …

Endocrine, nervous, and immune systems work coordinately to maintain the global
homeostasis of the organism. They show sex differences in their functions that, in turn …

Hematopoietic mosaic loss of Y chromosome (mLOY) has emerged as a potential male‐
specific accelerator of biological aging, increasing the risk of various age‐related diseases …

Background: Glyphosate is the most commonly used herbicide worldwide and has been
implicated in the development of certain hematologic cancers. Although mechanistic studies …