Amyloid diseases are a group of degenerative disorders characterized by cell/tissue
damage caused by toxic protein aggregates. Abnormal production, processing and/or …

β-cell death is regarded as a major event driving loss of insulin secretion and hyperglycemia
in both type 1 and type 2 diabetes mellitus. In this review, we explore past, present, and …

Human islet amyloid polypeptide (hIAPP) functions as a glucose-regulating hormone but
deposits as amyloid fibrils in more than 90% of patients with type II diabetes (T2D). Here we …

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD)
and type 2 diabetes. To determine if amyloid beta (Aβ) and hyperphosphorylated tau occurs …

Bacterial inclusion bodies are major bottlenecks in protein production, narrowing the
spectrum of relevant polypeptides obtained by recombinant DNA. While regarded as …

The protein islet amyloid polypeptide (IAPP) is a glucose metabolism associated hormone
cosecreted with insulin by the β‐cells of the pancreas. In humans with type 2 diabetes, IAPP …

The aggregation of alpha-synuclein (AS) is a critical step in the etiology of Parkinson's
disease (PD). A central, unresolved question in the pathophysiology of PD relates to the role …

Protein misfolding and aggregation into amyloid structures are associated with dozens of
human diseases. Recent studies have provided compelling evidence for the existence of …

Strong epidemiologic evidence and common molecular mechanisms support an association
between Alzheimer's disease (AD) and type 2-diabetes. Local inflammation and amyloidosis …

Escherichia coli is one of the most widely used hosts for the production of recombinant
proteins. However, very often the target protein accumulates into insoluble aggregates in a …