Lipid peroxidation can be described generally as a process under which oxidants such as
free radicals attack lipids containing carbon‐carbon double bond (s), especially …

The generation of reactive oxygen species (ROS) and an altered redox status are common
biochemical aspects in cancer cells. ROS can react with the polyunsaturated fatty acids of …

During the last three decades, 4-hydroxy-2-nonenal (HNE), a major α, β-unsaturated
aldehyde product of n-6 fatty acid oxidation, has been shown to be involved in a great …

Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage
and excess caloric intake cause generalized DNA damage, producing genotoxic and …

HRAS, NRAS and KRAS, collectively referred to as oncogenic RAS, are the most frequently
mutated driver proto-oncogenes in cancer. Oncogenic RAS aberrantly rewires metabolic …

Genomic instability is a common feature of cancer etiology. This provides an avenue for
therapeutic intervention, since cancer cells are more susceptible than normal cells to DNA …

Four new carboxylates complexes with general formula R2SnL2 and R3SnL, where R= n-
butyl (1, 3), methyl (2, 4) and L= 4-Chlorophenoxyacetate, were synthesized in significant …

Introduction Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has been found to
have therapeutic potential for treating cancers associated with impaired DNA repair …

Living organisms are continuously exposed to xenobiotics. The major phase of enzymatic
detoxification in many species is the conjugation of activated xenobiotics to reduced …

Panobinostat, also known as Farydak®, LBH589, PNB, or panobinostat lactate, is a
hydroxamic acid that has been approved by the Food and Drug Administration (FDA) for its …