Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its
cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in …

The majority of clinically approved anticancer drugs are characterized by a narrow
therapeutic window that results mainly from a high systemic toxicity of the drugs in …

Selective fluorescence imaging of biomarkers in vivo and in situ for evaluating orthotopic
hepatocellular carcinoma (HCC) chemotherapy remains a great challenge due to current …

Almost all therapeutic proteins are glycosylated, with the carbohydrate component playing a
long-established, substantial role in the safety and pharmacokinetic properties of this …

Organic carbamates are a stable class of compounds derived from the unstable carbamic
acid (H2NeCOOH) by substitution of the amino and carboxyl moieties with various kinds of …

Acetylcholinesterase (AChE) is a significant enzyme, which plays critical roles in numerous
physiological and pathological processes. Thus, selective, and sensitive real-time imaging …

Acetylcholinesterase (AChE) is an extremely critical hydrolase tightly associated with
neurological diseases. Currently, developing specific substrates for imaging AChE activity …

Dextran vesicular nanoscaffolds were developed based on polysaccharide and renewable
resource alkyl tail for dual encapsulation of hydrophilic and hydrophobic molecules (or …

The cytotoxicity of doxorubicin, a clinically used anti-neoplastic drug, can be enhanced by
formaldehyde (either endogenous or exogenous) to promote the formation of doxorubicin …

The main drawback of most cancer chemotherapy is its relatively low ability to target tumour
cells versus normal cells. As a consequence, chemotherapy is usually connected with …