Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

Abstract MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in
size, play important roles in gene regulation, and their dysregulation is implicated in human …

R-loops are non-B DNA structures with intriguing dual consequences for gene expression
and genome stability. In addition to their recognized roles in triggering DNA double-strand …

The m 6 A reader YT521-B homology containing 2 (YTHDC2) has been identified to inhibit
lung adenocarcinoma (LUAD) tumorigenesis by suppressing solute carrier 7A11 (SLC7A11) …

DNA end resection has a key role in double-strand break repair and DNA replication.
Defective DNA end resection can cause malfunctions in DNA repair and replication, leading …

Much of the mammalian genome is transcribed, generating long non-coding RNAs
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …

Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for
regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA …

Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …

The SWI/SNF family of ATP-dependent chromatin remodeling complexes is implicated in
multiple DNA damage response mechanisms and frequently mutated in cancer. The BAF …

DNA double-strand breaks and inter-strand cross-links are the most harmful types of DNA
damage that cause genomic instability that lead to cancer development. The highest fidelity …