Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

Cellular differentiation and lineage commitment are considered to be robust and irreversible
processes during development. Recent work has shown that mouse and human fibroblasts …

The stable states of differentiated cells are now known to be controlled by dynamic
mechanisms that can easily be perturbed. An adult cell can therefore be reprogrammed …

Certain morphological, physiological and molecular characteristics are shared by all
neurons. However, despite these similarities, neurons constitute the most diverse cell …

In adult hippocampus, new neurons are continuously generated from neural stem cells
(NSCs), but the molecular mechanisms regulating adult neurogenesis remain elusive. We …

OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the
pMN domain of the spinal cord, which sequentially generates motoneurons and …

The generation of neurons from stem cells involves the activity of proneural basic helix-loop-
helix (bHLH) proteins, but the mechanism by which these proteins irreversibly commit stem …

Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal
differentiation when expressed in neural progenitor cells. The mechanisms by which …

Radial glial cells, ubiquitous throughout the developing CNS, guide radially migrating
neurons and are the precursors of astrocytes. Recent evidence indicates that radial glial …