Reactive oxygen species (ROS): utilizing injectable antioxidative hydrogels and ROS-producing therapies to manage the double-edged sword

Z He, Q Xu, B Newland, R Foley, I Lara-Sáez… - Journal of Materials …, 2021 - pubs.rsc.org
Reactive oxygen species (ROS) are generated in cellular metabolism and are essential for
cellular signalling networks and physiological functions. However, the functions of ROS are …

Biotherapeutic-loaded injectable hydrogels as a synergistic strategy to support myocardial repair after myocardial infarction

Z Zheng, Y Tan, Y Li, Y Liu, G Yi, CY Yu… - Journal of Controlled …, 2021 - Elsevier
Myocardial infarction (MI) has been considered as the leading cause of cardiovascular-
related deaths worldwide. Although traditional therapeutic agents including various …

[HTML][HTML] Wet adhesive hydrogel cardiac patch loaded with anti-oxidative, autophagy-regulating molecule capsules and MSCs for restoring infarcted myocardium

T Wu, X Zhang, Y Liu, C Cui, Y Sun, W Liu - Bioactive Materials, 2023 - Elsevier
Hydrogel patch-based stem cell transplantation and microenvironment-regulating drug
delivery strategy is promising for the treatment of myocardial infarction (MI). However, the …

Reactive oxygen species scavenging with a biodegradable, thermally responsive hydrogel compatible with soft tissue injection

Y Zhu, Y Matsumura, M Velayutham, LM Foley… - Biomaterials, 2018 - Elsevier
Tissue damage and the impairment of regenerative processes by excessive reactive oxygen
species (ROS) contributes to the pathogenesis of various diseases in soft tissues including …

Ferulic acid alleviates myocardial ischemia reperfusion injury via upregulating AMPKα2 expression-mediated ferroptosis depression

X Liu, K Qi, Y Gong, X Long, S Zhu, F Lu… - Journal of …, 2022 - journals.lww.com
Ferroptosis, a recently discovered form of regulated cell death that is characterized by iron
accumulation and excessive reactive oxygen species generation, has been favored by most …

[HTML][HTML] CISD2 maintains cellular homeostasis

ZQ Shen, YL Huang, YC Teng, TW Wang… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for the disease
Wolfram syndrome 2 (WFS2; MIM 604928), which is an autosomal recessive disorder …

[HTML][HTML] Nanomaterial-based electrically conductive hydrogels for cardiac tissue repair

M Lee, MC Kim, JY Lee - International Journal of Nanomedicine, 2022 - ncbi.nlm.nih.gov
Cardiovascular disease is one of major causes of deaths, and its incidence has gradually
increased worldwide. For cardiovascular diseases, several therapeutic approaches, such as …

Progress in Stimuli‐Responsive Biomaterials for Treating Cardiovascular and Cerebrovascular Diseases

C Tapeinos, H Gao, T Bauleth‐Ramos, HA Santos - Small, 2022 - Wiley Online Library
Cardiovascular and cerebrovascular diseases (CCVDs) describe abnormal vascular system
conditions affecting the brain and heart. Among these, ischemic heart disease and ischemic …

Chitosan as functional biomaterial for designing delivery systems in cardiac therapies

B Patel, R Manne, DB Patel, S Gorityala… - Gels, 2021 - mdpi.com
Cardiovascular diseases are a leading cause of mortality across the globe, and transplant
surgeries are not always successful since it is not always possible to replace most of the …

Remodelers of the vascular microenvironment: The effect of biopolymeric hydrogels on vascular diseases

M Li, M Jin, H Yang - International Journal of Biological Macromolecules, 2024 - Elsevier
Vascular disease is the leading health problem worldwide. Vascular microenvironment
encompasses diverse cell types, including those within the vascular wall, blood cells …