Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …

The crosstalk among the complement system, immune cells, and mediators of inflammation
provides an efficient mechanism to protect the organism against infections and support the …

Alternative splicing affects more than 95% of multi-exon genes in the human genome. These
changes affect the proteome in a myriad of ways. Here, we review our understanding of the …

The term “intracellular complement” has been introduced recently as an umbrella term to
distinguish functions of complement proteins that take place intracellularly, rather than in the …

Diabetic vascular complications (DVCs), including macro-and micro-angiopathy, account for
a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial …

Recent rapid progress in key technological advances, including the broader accessibility of
single‐cell “omic” approaches, have allowed immunologists to gain important novel insights …

Non‐alcoholic fatty liver disease (NAFLD) is a growing public health threat and becoming
the leading cause of liver transplantation. Nevertheless, no approved specific treatment is …

The complement system is one of the immune system's oldest defense mechanisms and is
historically regarded as a liver-derived and serum-active innate immune system that …

The complement system, a key component of innate immunity, provides the first line of
defense against bacterial infection; however, the COVID-19 pandemic has revealed that it …