[HTML][HTML] The emerging role of ferroptosis in inflammation
Y Sun, P Chen, B Zhai, M Zhang, Y Xiang… - Biomedicine & …, 2020 - Elsevier
Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid
peroxidation that is morphologically, biologically and genetically distinct from other types of …
peroxidation that is morphologically, biologically and genetically distinct from other types of …
Iron complexes of flavonoids-antioxidant capacity and beyond
Z Kejík, R Kaplánek, M Masařík, P Babula… - International journal of …, 2021 - mdpi.com
Flavonoids are common plant natural products able to suppress ROS-related damage and
alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation …
alleviate oxidative stress. One of key mechanisms, involved in this phenomenon is chelation …
Inhibiting ferroptosis: A novel approach for stroke therapeutics
Highlights•This review briefly introduces the contributor role of ferroptosis in
stroke.•Ferroptosis inhibitors exhibit neuroprotective effects in multiple stroke models.•The …
stroke.•Ferroptosis inhibitors exhibit neuroprotective effects in multiple stroke models.•The …
Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives
P Hernández, M Cabrera, ML Lavaggi, L Celano… - Bioorganic & medicinal …, 2012 - Elsevier
We report the design, the synthesis and the biological evaluation of the analgesic and anti-
inflammatory activities of furoxanyl N-acylhydrazones (furoxanyl-NAH) by applying …
inflammatory activities of furoxanyl N-acylhydrazones (furoxanyl-NAH) by applying …
[HTML][HTML] Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs
T Manivarma, AA Kapralov, SN Samovich… - Free Radical Biology …, 2023 - Elsevier
Ferroptosis is a regulated form of cell death, the mechanism of which is still to be
understood. 15-lipoxygenase (15LOX) complex with phosphatidylethanolamine (PE) …
understood. 15-lipoxygenase (15LOX) complex with phosphatidylethanolamine (PE) …
The antiinflammatory potential of flavonoids: Mechanistic aspects
Flavonoids are a subclass of phenolic compounds that occur ubiquitously in food plants and
vegetables. This class of compounds shares a common 15-carbon structure represented by …
vegetables. This class of compounds shares a common 15-carbon structure represented by …
Exploring the free-energy landscapes of biological systems with steered molecular dynamics
LY Chen - Physical Chemistry Chemical Physics, 2011 - pubs.rsc.org
We perform steered molecular dynamics (SMD) simulations and use the Brownian dynamics
fluctuation-dissipation-theorem (BD-FDT) to accurately compute the free-energy profiles for …
fluctuation-dissipation-theorem (BD-FDT) to accurately compute the free-energy profiles for …
In silico study of Aquaporin V: Effects and affinity of the central pore-occluding lipid
Because of its roles in human physiology, Aquaporin V (AQP5), a major intrinsic protein, has
been a subject of many in vitro studies. In particular, a 2008 experiment produced its crystal …
been a subject of many in vitro studies. In particular, a 2008 experiment produced its crystal …
Structural investigation of selective binding dynamics for the pheromone‐binding protein 1 of the grapevine moth, Lobesia botrana
H Venthur, J Machuca, R Godoy… - Archives of insect …, 2019 - Wiley Online Library
Abstract The European grapevine moth, Lobesia botrana (Denis & Schiffermüller), is a
serious pest in vineyards in North and South America. Mating disruption techniques have …
serious pest in vineyards in North and South America. Mating disruption techniques have …
Emerging targets in lipid-based therapy
SC Tucker, KV Honn - Biochemical pharmacology, 2013 - Elsevier
The use of prostaglandins and NSAIDS in the clinic has proven that lipid mediators and their
associated pathways make attractive therapeutic targets. When contemplating therapies …
associated pathways make attractive therapeutic targets. When contemplating therapies …