T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and
to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP …

The function of the Src-family kinases (SFKs) Lck and Fyn in T cells has been intensively
studied over the past 15 years. Animal models and cell line studies both indicate a critical …

In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

The naïve and memory T lymphocyte pools are maintained through poorly understood
homeostatic mechanisms that may include signaling via cytokine receptors. We show that …

In T cell-deficient conditions, naïve T cells undergo spontaneous “homeostatic” proliferation
in response to contact with self-MHC/peptide ligands. With the aid of an in vitro system, we …

Members of the Bcl-2 family are crucial integrators of survival and death signals in higher
eukaryotes. Although recent studies have provided novel and quite unexpected insights into …

The immune response is initiated in organized lymphoid tissues where antigen-loaded
dendritic cells (DCs) encounter antigen-specific T cells. DCs function as packets of …

The persistence of naive and memory T cells has long been of interest to immunologists, but
the factors that influence the survival and homeostasis of these subsets have remained …

T cells require continual presence of extrinsic signals from their in vivo microenvironment to
maintain viability. T cells removed from these signals and placed in tissue culture atrophied …

Both naive and memory T cells undergo antigen-independent proliferation after transfer into
a T cell–depleted environment (acute homeostatic proliferation), whereas only memory T …