Lower extremity amputation (LEA) in patients with diabetes results in high mortality, reduced
quality of life, and increased medical costs. Exact data on incidences of LEA in diabetic and …

Critical limb ischemia (CLI) is considered the most severe pattern of peripheral artery
disease. It is defined by the presence of chronic ischemic rest pain, ulceration or gangrene …

Abstract The International Working Group on the Diabetic Foot (IWGDF) has published
evidence‐based guidelines on the prevention and management of diabetic foot disease …

Critical limb ischemia, first defined in 1982, was intended to delineate a subgroup of patients
with a threatened lower extremity primarily because of chronic ischemia. It was the intent of …

Background Diabetes mellitus continues to grow in global prevalence and to consume an
increasing amount of health care resources. One of the key areas of morbidity associated …

Recommendations Examine a patient with diabetes annually for the presence of peripheral
artery disease (PAD); this should include, at a minimum, taking a history and palpating foot …

Every 30 s, a lower limb is amputated due to diabetes. Of all amputations in diabetic patients
85% are preceded by a foot ulcer which subsequently deteriorates to a severe infection or …

Ulcerated diabetic foot is a complex problem. Ischaemia, neuropathy and infection are the
three pathological components that lead to diabetic foot complications, and they frequently …

In 2015, it can be said that the diabetic foot is no longer the Cinderella of diabetic
complications. Thirty years ago there was little evidence‐based research taking place on the …

Background Foot ulcers are a major complication of diabetes mellitus, often leading to
amputation. Growth factors derived from blood platelets, endothelium, or macrophages …