Large-scale plasma proteomics comparisons through genetics and disease associations

GH Eldjarn, E Ferkingstad, SH Lund, H Helgason… - Nature, 2023 - nature.com
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …

[HTML][HTML] 25 Years of translational research in the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC)

H Bisgaard, B Chawes, J Stokholm, M Mikkelsen… - Journal of Allergy and …, 2023 - Elsevier
The Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) mother-child
cohorts have provided a foundation of 25 years of research on the origins, prevention, and …

[HTML][HTML] Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age

A Morin, CG McKennan, CET Pedersen… - Journal of Allergy and …, 2020 - Elsevier
Background The upper airways present a barrier to inhaled allergens and microbes, which
alter immune responses and subsequent risk for diseases, such as allergic rhinitis (AR) …

Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB

AU Eliasen, CET Pedersen, MA Rasmussen… - Journal of Allergy and …, 2022 - Elsevier
Background Asthma with severe exacerbation is one of the most common causes of
hospitalization among young children. Exacerbations are typically triggered by respiratory …

The changes in bacterial microbiome associated with immune disorder in allergic respiratory disease

J Lyu, F Kou, X Men, Y Liu, L Tang, S Wen - Microorganisms, 2022 - mdpi.com
Allergic respiratory disease is a worldwide and increasingly prevalent health problem. Many
researchers have identified complex changes in the microbiota of the respiratory and …

[PDF][PDF] Analysis of the expression changes of IL-17+ γδ T cells and Treg cells in bone marrow mesenchymal stem cells targeted therapy for allergic rhinitis.

B Zou, RX Zhuang, XY Sun… - European Review for …, 2021 - europeanreview.org
OBJECTIVE: Bone marrow mesenchymal stem cells (BMSCs) have immunomodulatory and
therapeutic effects on immune system diseases. This study intends to assess the regulatory …

Dust mite component Analysis: Identifying key allergens components for effective immunotherapy in allergic rhinitis

J Huang, R Xiang, L Tan, Y Deng, Z Tao… - International …, 2023 - Elsevier
Background The aim of this study was to examine the frequency of sensitization to house
dust mite (HDM) components among allergic rhinitis patients receiving subcutaneous …

Bilirubin metabolism in early life and respiratory health during preschool age: A combined analysis of two independent birth cohorts

M Kim, N Brustad, AU Eliasen, M Ali, T Wang… - Med, 2024 - cell.com
Background Bilirubin has antioxidant properties, and elevated levels within the normal
range have been associated with improved lung function and decreased risk of asthma in …

Clinical significance of T helper-1/T helper-2 cytokines in peripheral blood of children with otitis media with effusion and allergic rhinitis

L Yu, J Bi, B Xu, B Yu, Y Fu - International Journal of Pediatric …, 2024 - Elsevier
Objective Otitis media with effusion (OME) is a prevalent and costly disease, especially in
children. This article analyzed the expression patterns and clinical significance of T helper-1 …

Allergen alters IL‐2/αIL‐2‐based Treg expansion but not tolerance induction in an allergen‐specific mouse model

C Köhler, U Smole, B Kratzer, D Trapin… - Allergy, 2020 - Wiley Online Library
Abstract Background Regulatory T lymphocytes (Treg) play an important role in preventing
allergic diseases. We characterized Treg expansion kinetics, marker profiles, and …