Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis

WM Wiersinga, KG Poppe… - The lancet Diabetes & …, 2023 - thelancet.com
Hyperthyroidism is a common condition with a global prevalence of 0· 2–1· 3%. When
clinical suspicion of hyperthyroidism arises, it should be confirmed by biochemical tests (eg …

Immune related adverse events of the thyroid–a narrative review

CA Muir, VHM Tsang, AM Menzies… - Frontiers in …, 2022 - frontiersin.org
Immune checkpoints are small molecules present on the cell surface of T-lymphocytes. They
maintain self-tolerance and regulate the amplitude and duration of T-cell responses …

Thyroid immune-related adverse events following immune checkpoint inhibitor treatment

CA Muir, RJ Clifton-Bligh, GV Long… - The Journal of …, 2021 - academic.oup.com
Context Thyroid dysfunction occurs commonly following immune checkpoint inhibition. The
etiology of thyroid immune-related adverse events (irAEs) remains unclear and clinical …

Clonally expanded, thyrotoxic effector CD8+ T cells driven by IL-21 contribute to checkpoint inhibitor thyroiditis

MG Lechner, Z Zhou, AT Hoang, N Huang… - Science translational …, 2023 - science.org
Autoimmune toxicity occurs in up to 60% of patients treated with immune checkpoint inhibitor
(ICI) therapy for cancer and represents an increasing clinical challenge for expanding the …

Cutaneous adverse events and cancer survival prognosis with immune checkpoint inhibitor treatment: a systematic review and meta-analysis

Y Du, W Wu, M Chen, Z Dong, F Wang - Jama Dermatology, 2023 - jamanetwork.com
Importance Growing research suggests that the prevalence of cutaneous immune-related
adverse events (cirAEs) is associated with favorable outcomes among individuals with …

Inhibition of IL-17A protects against thyroid immune-related adverse events while preserving checkpoint inhibitor antitumor efficacy

MG Lechner, MI Cheng, AY Patel… - The Journal of …, 2022 - journals.aai.org
Immune checkpoint inhibitor (ICI) immunotherapy leverages the body's own immune system
to attack cancer cells but leads to unwanted autoimmune side effects in up to 60% of …

Management of endocrine and metabolic toxicities of immune-checkpoint inhibitors: from clinical studies to a real-life scenario

CC Spagnolo, G Giuffrida, S Cannavò, T Franchina… - Cancers, 2022 - mdpi.com
Simple Summary Immune checkpoint inhibitors currently represent the standard of care for
the treatment of different tumor types and have also been proven to be effective in several …

Clinical presentation of immune-related endocrine adverse events during immune checkpoint inhibitor treatment

JHL Chieng, ZW Htet, JJ Zhao, ES Tai, SH Tay… - Cancers, 2022 - mdpi.com
Simple Summary With the growing use of immune checkpoint inhibitors (ICIs), clinicians are
increasingly encountering a unique set of adverse events called immune-related adverse …

[HTML][HTML] Electrocardiographic features of immune checkpoint inhibitor-associated myocarditis

W Song, Y Zheng, M Dong, L Zhong, G Bazoukis… - Current Problems in …, 2023 - Elsevier
Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events
including myocarditis, whilst improving cancer-related outcomes. There is thus a clinical …

[HTML][HTML] Thyroid dysfunction after atezolizumab and bevacizumab is associated with favorable outcomes in hepatocellular carcinoma

YS Song, H Yang, B Kang, J Cheon, I Kim, H Kim… - Liver Cancer, 2024 - karger.com
Abstract Introduction: Atezolizumab and bevacizumab (Ate/Bev) combination has become
the new first-line systemic therapy for unresectable hepatocellular carcinoma (HCC) …