Radiotherapy and chemotherapy are two famous modalities in tumor‐targeted therapy that
lead to systemic and local toxicities for normal tissues. Moreover, several studies have …

Background: Nowadays, ionizing radiation is used for several applications in medicine,
industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing …

Streptococcus pneumoniae is a major cause of pneumonia in infants and the elderly. Innate
defenses are essential to the control of pneumococcal infections, and deficient responses …

Allergic asthma is a complex disease characterized by eosinophilic pulmonary inflammation,
mucus production and reversible airway obstruction. Exposure to indoor allergens is a risk …

Purpose: There is increasing concern that, since the Cold War era, there has been little
progress regarding the availability of medical countermeasures in the event of either a …

The body senses “danger” from “damaged self” molecules through members of the same
receptor superfamily it uses for microbial “non-self”, triggering canonical signaling pathways …

In adaptive immunity, Th17 lymphocytes produce the IL-17 and IL-22 cytokines that stimulate
mucosal antimicrobial defenses and tissue repair. In this study, we observed that the TLR5 …

Due to the radiosensitivity of the lung, toxic endpoints, in the form of radiation pneumonitis
and pulmonary fibrosis, are relatively frequent outcomes following radiation treatment of …

Motility is often a pathogenicity determinant of bacteria targeting mucosal tissues. Flagella
constitute the machinery that propels bacteria into appropriate niches. Besides motility, the …

There are currently no approved medical radiation countermeasures (MRC) to reduce the
lethality of high-dose total body ionizing irradiation expected in nuclear emergencies. An …