Electrochemical enaminone C–H thiolation/C–N amination cascade for thiazole synthesis and its diastereoselective dearomatization

H Guo, Y Liu, C Wen, JP Wan - Green Chemistry, 2022 - pubs.rsc.org
An electrochemical method for the synthesis of 2-aminothiazoles via aryl ring construction
using enaminones and thioureas is reported. The cascade enamine C–H thiolation and C–N …

Selective detection of metal ions, sulfites and glutathione with fluorescent pyrazolines: a review

L Săcărescu, AL Chibac-Scutaru, G Roman… - Environmental …, 2023 - Springer
Pollution by toxic metals is a worldwide health issue, yet analytical methods to monitor
selectively metal ions in complex media are limited. Fluorescence sensing using pyrazolines …

Development of bromo-and fluoro-based α, β-unsaturated ketones as highly potent MAO-B inhibitors for the treatment of Parkinson's disease

MA Abdelgawad, JM Oh, DGT Parambi, S Kumar… - Journal of Molecular …, 2022 - Elsevier
This study evaluated the synthesis of a dual series of bromo (CHB1–CHB4)-and fluoro
(CHF1–CHF4)-based α, β-unsaturated ketones and their inhibitory activities against …

Synthesis, biological screening and in silico studies of new N-phenyl-4-(1, 3-diaryl-1H-pyrazol-4-yl) thiazol-2-amine derivatives as potential antifungal and …

Y Nandurkar, MR Bhoye, D Maliwal… - European Journal of …, 2023 - Elsevier
A new series of N-aryl-4-(1, 3-diaryl-1H-pyrazol-4-yl) thiazol-2-amine,(8a-x) have been
synthesized by a cyclo-condensation reaction of 2-bromo-1-(1, 3-diphenyl-1H-pyrazol-4-yl) …

Design and synthesis of carbothioamide/carboxamide-based pyrazoline analogs as potential anticancer agents: apoptosis, molecular docking, ADME assay, and DNA …

M Rana, MI Faizan, SH Dar, T Ahmad, Rahisuddin - ACS omega, 2022 - ACS Publications
To discover anticancer drugs with novel structures and expand our research scope,
pyrazoline derivatives (3a–3l) were designed and synthesized through cyclization of …

Recent literature on the synthesis of thiazole derivatives and their biological activities

TA Farghaly, GH Alfaifi… - Mini Reviews in Medicinal …, 2024 - ingentaconnect.com
The thiazole ring is naturally occurring and is primarily found in marine and microbial
sources. It has been identified in various compounds such as peptides, vitamins (thiamine) …

Novel tryptanthrin derivatives with benzenesulfonamide substituents: Design, synthesis, and anti-inflammatory evaluation

J Du, P Liu, Y Zhu, G Wang, S Xing, T Liu, J Xia… - European Journal of …, 2023 - Elsevier
Herein, two series of tryptanthrin derivatives with benzenesulfonamide substituents were
designed and synthesized to discover novel anti-inflammatory agents. The anti-inflammatory …

Novel flavonoid 1, 3, 4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway

HW Meng, ZB Shen, XS Meng, ZQ Yin, XR Wang… - Bioorganic …, 2023 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder with a complex
etiology. Neuroinflammation and oxidative stress are important factors driving the …

Design, synthesis, and SAR study of novel flavone 1, 2, 4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease

ZB Shen, HW Meng, XS Meng, ZK Lv, MY Fang… - European Journal of …, 2023 - Elsevier
Inflammation is one of a major feature of Parkinson's disease (PD) which poses a threat to
people's health in the world. It has been reported that antioxidation and anti-inflammation …

Design, synthesis, anticancer evaluation, and in silico studies of some thieno[2,3‐d]pyrimidine derivatives as EGFR inhibitors

MTM Sayed, PA Halim, AK El‐Ansary… - Drug Development …, 2023 - Wiley Online Library
Abstract New series of 20 thieno [2, 3‐d] pyrimidine derivatives have been synthesized. The
National Cancer Institute evaluated all the newly synthesized compounds for their …