Multiple sclerosis: mechanisms and immunotherapy

C Baecher-Allan, BJ Kaskow, HL Weiner - Neuron, 2018 - cell.com
Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act
on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …

The sequence of disease-modifying therapies in relapsing multiple sclerosis: safety and immunologic considerations

G Pardo, DE Jones - Journal of neurology, 2017 - Springer
The treatment landscape for relapsing forms of multiple sclerosis (RMS) has expanded
considerably over the last 10 years with the approval of multiple new disease-modifying …

Increased perfusion in normal appearing white matter in high inflammatory multiple sclerosis patients

M Bester, ND Forkert, JP Stellmann, L Aly, A Drabik… - PLoS …, 2015 - journals.plos.org
Purpose Although cerebral perfusion alterations have long been acknowledged in multiple
sclerosis (MS), the relationship between measurable perfusion changes and the status of …

Application of advanced MRI techniques to monitor pharmacologic and rehabilitative treatment in multiple sclerosis: current status and future perspectives

MA Rocca, P Preziosa, M Filippi - Expert Review of …, 2019 - Taylor & Francis
Introduction: Advances in magnetic resonance imaging (MRI) technology and analyses are
improving our understanding of the pathophysiology of multiple sclerosis (MS). Due to their …

Therapeutic efficacy of monthly subcutaneous injection of daclizumab in relapsing multiple sclerosis

S Cohan - Biologics: Targets and Therapy, 2016 - Taylor & Francis
Despite the availability of multiple disease-modifying therapies for relapsing multiple
sclerosis (MS), there remains a need for highly efficacious targeted therapy with a favorable …

Daclizumab: a review in relapsing multiple sclerosis

M Shirley - Drugs, 2017 - Springer
Daclizumab (Zinbryta®; previously known as daclizumab high-yield process) is a
therapeutic monoclonal antibody that has recently been approved for the treatment of …

Emerging immunopharmacological targets in multiple sclerosis

M Farjam, GX Zhang, B Ciric, A Rostami - Journal of the neurological …, 2015 - Elsevier
Inflammatory demyelination of the central nervous system (CNS) is the hallmark of multiple
sclerosis (MS), a chronic debilitating disease that affects more than 2.5 million individuals …

Treatment of experimental autoimmune encephalomyelitis using AAV gene therapy by blocking T cell costimulatory pathways

C Zhong, Z Chen, Y Xia, J Wu, F Zhang… - … Therapy-Methods & …, 2022 - cell.com
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
(CNS), characterized by inflammation and demyelination. Presently, repeated relapses of …

Identification of patients with relapsing multiple sclerosis eligible for high-efficacy therapies

J Meca-Lallana, JA García-Merino… - Neurodegenerative …, 2021 - Taylor & Francis
Relapsing multiple sclerosis (RMS) presents a highly variable clinical evolution among
patients, and its management should be personalized. Although there is no cure at present …

Daclizumab

AP Kim, DE Baker - Hospital pharmacy, 2016 - journals.sagepub.com
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-
documented monographs on drugs that are newly released or are in late phase 3 trials. The …