Defects in apoptotic pathways can promote cancer cell survival and also confer resistance to
antineoplastic drugs. One pathway being targeted for antineoplastic therapy is the anti …

This review deals with the permeability transition (PT) of isolated mitochondria, a field
spawned at the very beginning of mitochondrial research by the observation that the …

Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

Reactive oxygen species (ROS) are known mediators of intracellular signal cascades.
Excessive production of ROS may lead to oxidative stress, loss of cell function, and cell …

Up to 2% of the oxygen consumed by the mitochondrial respiratory chain undergoes one
electron reduction, typically by the semiquinone form of coenzyme Q, to generate the …

Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Mitochondrial permeability transition (MPT) is a non-selective inner membrane
permeabilization that may precede necrotic and apoptotic cell death. Although this process …

Reactive oxygen (ROS) and nitrogen oxide (RNOS) species are produced as by-products of
oxidative metabolism. A major function for ROS and RNOS is immunological host defense …

In clinical settings, oxygen therapy is administered to preterm neonates and to adults with
acute and chronic conditions such as COVID-19, pulmonary fibrosis, sepsis, cardiac arrest …