Virus-like particle vaccinology, from bench to bedside

MO Mohsen, MF Bachmann - Cellular & molecular immunology, 2022 - nature.com
Virus-like particles (VLPs) have become key tools in biology, medicine and even
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …

[HTML][HTML] Opportunities and challenges for human papillomavirus vaccination in cancer

R Roden, PL Stern - Nature Reviews Cancer, 2018 - nature.com
The discovery of genotype 16 as the prototype oncogenic human papillomavirus (HPV)
initiated a quarter century of laboratory and epidemiological studies that demonstrated their …

Design of virus-based nanomaterials for medicine, biotechnology, and energy

AM Wen, NF Steinmetz - Chemical Society Reviews, 2016 - pubs.rsc.org
This review provides an overview of recent developments in “chemical virology.” Viruses, as
materials, provide unique nanoscale scaffolds that have relevance in chemical biology and …

Lead SARS-CoV-2 candidate vaccines: expectations from phase III trials and recommendations post-vaccine approval

E Tumban - Viruses, 2020 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted primarily
through respiratory droplets/aerosols and it causes COVID-19. The virus infects epithelial …

Virus-like particles as preventive and therapeutic cancer vaccines

AL Tornesello, M Tagliamonte, FM Buonaguro… - Vaccines, 2022 - mdpi.com
Virus-like particles (VLPs) are self-assembled viral protein complexes that mimic the native
virus structure without being infectious. VLPs, similarly to wild type viruses, are able to …

Engineering virus-like particles as vaccine platforms

KM Frietze, DS Peabody, B Chackerian - Current opinion in virology, 2016 - Elsevier
Highlights•VLP have been engineered to improve their utility as vaccine platforms.•Targeted
engineering of VLPs has enhanced immunogenicity, stability, and versatility.•Predictive …

Virus-like particle vaccines: immunology and formulation for clinical translation

B Donaldson, Z Lateef, GF Walker… - Expert review of …, 2018 - Taylor & Francis
Introduction: Virus-like particle (VLP) vaccines face significant challenges in their translation
from laboratory models, to routine clinical administration. While some VLP vaccines thrive …

Gardasil-9: A global survey of projected efficacy

L Zhai, E Tumban - Antiviral research, 2016 - Elsevier
Human papillomaviruses (HPVs) are the causative agents of human neoplasias such as
warts and cancers. There are∼ 19 HPV types associated with cancers, which has made it …

Phage‐enabled nanomedicine: from probes to therapeutics in precision medicine

KS Sunderland, M Yang, C Mao - … Chemie International Edition, 2017 - Wiley Online Library
Both lytic and temperate bacteriophages (phages) can be applied in nanomedicine, in
particular, as nanoprobes for precise disease diagnosis and nanotherapeutics for targeted …

RG1-VLP and other L2-based, broad-spectrum HPV vaccine candidates

B Huber, JW Wang, RBS Roden… - Journal of Clinical …, 2021 - mdpi.com
Licensed human papillomavirus (HPV) vaccines contain virus-like particles (VLPs) self-
assembled from L1 major-capsid proteins that are remarkably effective prophylactic …