The Evolving Immunotherapy Landscape and the Epidemiology, Diagnosis, and Management of Cardiotoxicity: JACC: CardioOncology Primer

L Zhang, KL Reynolds, AR Lyon, N Palaskas… - Cardio Oncology, 2021 - jacc.org
Immune checkpoint inhibitors (ICIs) are newer therapies being applied to an increasing
number of patients with cancer. Data suggest that up to 36% of cancer patients may be …

[HTML][HTML] Cardiac toxicity associated with immune checkpoint inhibitors: a systematic review

W Shalata, A Abu-Salman, R Steckbeck… - Cancers, 2021 - mdpi.com
Simple Summary This review article addresses the toxic effects on the heart associated with
the use of certain cancer-treating drugs known as immune checkpoint inhibitors. These …

Association between immune checkpoint inhibitors with cardiovascular events and atherosclerotic plaque

ZD Drobni, RM Alvi, J Taron, A Zafar, SP Murphy… - Circulation, 2020 - Am Heart Assoc
Background: Immune checkpoint inhibitors (ICIs) treat an expanding range of cancers.
Consistent basic data suggest that these same checkpoints are critical negative regulators of …

Cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis

L Zhang, M Awadalla, SS Mahmood… - European heart …, 2020 - academic.oup.com
Aims Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI).
Sparse data exist on the use of cardiovascular magnetic resonance (CMR) in ICI-associated …

Cardiovascular events among adults treated with chimeric antigen receptor T-cells (CAR-T)

RM Alvi, MJ Frigault, MG Fradley, MD Jain… - Journal of the American …, 2019 - jacc.org
Background: Chimeric antigen receptors redirect T cells (CAR-T) to target cancer cells.
There are limited data characterizing cardiac toxicity and cardiovascular (CV) events among …

Global longitudinal strain and cardiac events in patients with immune checkpoint inhibitor-related myocarditis

M Awadalla, SS Mahmood, JD Groarke… - Journal of the American …, 2020 - jacc.org
Background There is a need for improved methods for detection and risk stratification of
myocarditis associated with immune checkpoint inhibitors (ICIs). Global longitudinal strain …

Myocardial T1 and T2 mapping by magnetic resonance in patients with immune checkpoint inhibitor–associated myocarditis

P Thavendiranathan, L Zhang, A Zafar… - Journal of the American …, 2021 - jacc.org
Background Myocarditis is a potentially fatal complication of immune checkpoint inhibitor
(ICI) therapy. Data on the utility of cardiovascular magnetic resonance (CMR) T1 and T2 …

[HTML][HTML] Immune checkpoint inhibitors for cancer and venous thromboembolic events

J Gong, ZD Drobni, RM Alvi, SP Murphy… - European Journal of …, 2021 - Elsevier
Abstract Background Immune checkpoint inhibitors (ICIs) are widely used cancer treatments.
There are limited data on the risk for developing venous thromboembolism (VTE) among …

[HTML][HTML] Cardiovascular toxicity of immune checkpoint inhibitors in cancer patients: A review when cardiology meets immuno-oncology

DY Chen, WK Huang, VCC Wu, WC Chang… - Journal of the Formosan …, 2020 - Elsevier
Immune checkpoint inhibitors (ICIs) are a novel treatment option for cancer therapy, which
help direct the immune system to recognize and target cancer cells. ICIs have been shown …

[HTML][HTML] Immune checkpoint inhibitors and cardiac toxicity in patients treated for non-small lung cancer: a review

G Sławiński, A Wrona, A Dąbrowska-Kugacka… - International Journal of …, 2020 - mdpi.com
Lung cancer is a major cause of cancer-related mortality worldwide, both in men and
women. The vast majority of patients are diagnosed with non-small-cell lung cancer …