The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-N-acetyl
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …

Clinical symptom worsening in patients with multiple sclerosis (MS) is driven by
inflammation compartmentalized within the CNS, which results in chronic neuronal damage …

Background In the demyelinating disease multiple sclerosis (MS), chronic-active brain
inflammation, remyelination failure and neurodegeneration remain major issues despite …

Background Glycans play essential functional roles in the nervous system and their
pathobiological relevance has become increasingly recognized in numerous brain …

Impaired T cell immunity with aging increases mortality from infectious disease. The
branching of asparagine-linked glycans is a critical negative regulator of T cell immunity …

Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales,
from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype …

Glycosylation has a profound influence on protein activity and cell biology through a variety
of mechanisms, such as protein stability, receptor interactions and signal transduction. In …

Introduction Microbiota and their interaction with hosts have been of great interest in brain
research in recent years. However, the role of oral microbiota in mental illness and the …

Background Intrathecal clonal expansion of antibody-producing plasma cells in multiple
sclerosis (MS) perpetuates central nervous system injury and is associated with active …

Abstract Defects in Coenzyme Q (CoQ) metabolism have been associated with primary
mitochondrial disorders, neurodegenerative diseases and metabolic conditions. The …