The transcriptional regulator STAT3 has key roles in vertebrate development and mature
tissue function including control of inflammation and immunity. Mutations in human STAT3 …

Multiple sclerosis (MS) is a common autoimmune disease that targets myelin in the central
nervous system (CNS). Multiple genome-wide association studies (GWAS) over the past 10 …

The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …

Monogenic causes of autoimmunity provide key insights into the complex regulation of the
immune system. We report a new monogenic cause of autoimmunity resulting from de novo …

Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …

Complex disease genetics has been revolutionised in recent years by the advent of genome-
wide association (GWA) studies. The chronic inflammatory bowel diseases (IBDs), Crohn's …

INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …

Genome-wide association studies have revolutionised the genetic analysis of multiple
sclerosis. Through international collaborative efforts involving tens of thousands of cases …

Multiple sclerosis (MS) is a prevalent inflammatory disease of the central nervous system
that often leads to disability in young adults. Treatment options are limited and often only …

Cytokines play crucial roles in coordinating the activities of innate and adaptive immune
systems. In response to pathogen recognition, innate immune cells secrete cytokines that …