The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

The CB 1 and CB 2 cannabinoid receptors (CB 1 R, CB 2 R) are members of the G protein-
coupled receptor (GPCR) family that were identified over 20 years ago. CB 1 Rs and CB 2 …

Marijuana/cannabinoid research has been transformed into mainstream science during the
last half-century. Evidence based research and remarkable biotechnological advances …

Two well‐characterized cannabinoid receptors (CBrs), CB1 and CB2, mediate the effects of
cannabinoids and marijuana use, with functional evidence for other CBrs. CB1 receptors are …

The endogenous cannabinoids bind to and activate two G protein-coupled receptors, the
predominantly central cannabinoid receptor type 1 (CB1) and peripheral cannabinoid …

It is well known that certain active ingredients of the plants of Cannabis genus, ie, the
“phytocannabinoids”[pCBs; eg,(−)-trans-Δ9-tetrahydrocannabinol (THC),(−)-cannabidiol …

2-Arachidonoylglycerol (2-AG) is a unique molecular species of monoacylglycerol isolated
in 1995 from rat brain and canine gut as an endogenous ligand for the cannabinoid …

Objective To assess the safety and efficacy of lenabasum in diffuse cutaneous systemic
sclerosis (dc SS c). Methods A randomized, double‐blind, placebo‐controlled, phase II study …

Background Addiction and major depression are mental health problems associated with
stressful events in life with high relapse and reoccurrence even after treatment. Many …

Endocannabinoid levels appear to be transiently elevated as an adaptive reaction to re-
establish normal homeostasis when this is acutely and pathologically perturbed. In some …