Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Background Radioresistance is a major factor leading to the failure of radiotherapy and poor
prognosis in tumor patients. Following the application of radiotherapy, the activity of various …

The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to
recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of …

There are over 120 types of brain tumor and approximately 45% of primary brain tumors are
gliomas, of which glioblastoma multiforme (GBM) is the most common and aggressive with a …

Immune checkpoint blockade (ICB) has revolutionised the treatment of solid tumours, yet
most patients do not derive a clinical benefit. Resistance to ICB is often contingent on the …

Metabolic reprogramming in tumors represents a potential therapeutic target. Herein we
used shRNA depletion and a novel lactate dehydrogenase (LDHA) inhibitor, GNE-140, to …

Hyperpolarised magnetic resonance imaging (HP 13C-MRI) is an emerging clinical
technique to detect [1-13C] lactate production in prostate cancer (PCa) following intravenous …

Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with
cell metabolism that represents a novel epigenetic code affecting the fate of cells including …

Background: The hypoxia marker pimonidazole is a candidate biomarker of cancer
aggressiveness. We investigated the transcriptional programme associated with …

Abstract Background Hyperpolarized (HP) 13C-pyruvate MRI is a stable-isotope molecular
imaging modality that provides real-time assessment of the rate of metabolism through …