The human cellular genome is under constant stress from extrinsic and intrinsic factors,
which can lead to DNA damage and defective replication. In normal cells, DNA damage …

Multi-protein DNA replication complexes called replisomes perform the essential process of
copying cellular genetic information prior to cell division. Under ideal conditions, replisomes …

Stalled replication forks are a critical problem for the cell because they can lead to complex
genome rearrangements that underlie cell death and disease. Processes such as DNA …

CRISPR-Cas is a prokaryotic immune system built from capture and integration of invader
DNA into CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) loci, termed …

Bacterial replisomes often dissociate from replication forks before chromosomal replication
is complete. To avoid the lethal consequences of such situations, bacteria have evolved …

Collisions between cellular DNA replication machinery (replisomes) and damaged DNA or
immovable protein complexes can dissociate replisomes before the completion of …

PriA, a 3′→ 5′ superfamily 2 DNA helicase, acts to remodel stalled replication forks and
as a specificity factor for origin-independent assembly of a new replisome at the stalled fork …

In bacteria, replication forks assembled at a replication origin travel to the terminus, often a
few megabases away. They may encounter obstacles that trigger replisome disassembly …

DNA replication restart, the essential process that reinitiates prematurely terminated genome
replication reactions, relies on exquisitely specific recognition of abandoned DNA replication …

The Escherichia coli single‐strand DNA binding protein (SSB) is essential to viability where
it functions to regulate SSB interactome function. Here it binds to single‐stranded DNA and …