Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Cardiometabolic diseases have become a leading cause of morbidity and mortality globally.
They have been tightly linked to microbiome taxonomic and functional composition, with diet …

A growing body of evidence suggests interplay between the gut microbiota and the
pathogenesis of nonalcoholic fatty liver disease (NAFLD). However, the role of the gut …

Previous microbiome and metabolome analyses exploring non-communicable diseases
have paid scant attention to major confounders of study outcomes, such as common, pre …

Multiomic profiling can reveal population heterogeneity for both health and disease states.
Obesity drives a myriad of metabolic perturbations and is a risk factor for multiple chronic …

Despite milestones in preventive measures and treatment, cardiovascular disease (CVD)
remains associated with a high burden of morbidity and mortality. The protracted nature of …

The gut microbiome and its metabolites are increasingly implicated in several
cardiovascular diseases, but their role in human myocardial infarction (MI) injury responses …

Blood metabolome is commonly used in human studies to explore the associations of gut
microbiota-derived metabolites with cardiometabolic diseases. Here, in a cohort of 1007 …

Background There is a growing body of evidence suggesting that disturbance of the gut-
brain axis may be one of the potential causes of major depressive disorder (MDD). However …

Humans possess abundant amounts of microorganisms, including bacteria, fungi, viruses,
and archaea, in their gut. Patients with nonalcoholic fatty liver disease (NAFLD) exhibit …