Gene therapy with adeno-associated virus (AAV) vectors has demonstrated safety and long-
term efficacy in a number of trials across target organs, including eye, liver, skeletal muscle …

Review on mannose receptor as an endocytic receptor in antigen delivery that is co-
expressed with the microRNA miR-511-3p encoded within the Mrc1 gene. The MR is a …

There are slightly over 165 recombinant pharmaceuticals currently approved for human use.
Another 500 protein candidates are in preclinical and clinical development, about 70% of …

Mannose receptor (MR) is a C-type lectin primarily expressed by macrophages and dendritic
cells. Its three distinct extracellular binding sites recognise a wide range of both endogenous …

Adeno-associated viruses (AAV) have emerged as the lead vector in clinical trials and form
the basis for several approved gene therapies for human diseases, mainly owing to their …

Recent evidence revealed that presentation of soluble antigens is governed by the
endocytosis mechanisms that determine the intracellular routing of the endocytosed …

The subcutaneous route of administration has provided convenient and non-inferior delivery
of therapeutic proteins compared to intravenous infusion, but there is potential for enhanced …

N-glycosylation is one of major post-translational modifications in nature, and it is essential
for protein structure and function. As hydrophilic moieties of glycoproteins, N-glycans play …

Six recombinant factor VIII (rFVIII) products have been marketed worldwide. In 2013, the
Research of Determinants of Inhibitor Development (RODIN) study group reported an …

The mannose receptor is a member of the C-type lectin (CLEC) family, which can bind and
internalize a variety of endogenous and pathogen-associated ligands. Because of these …