Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid tumors with
an overall five-year survival rate of that has only just reached 10%. The tumor …

The poor prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is partially
attributed to the invasive and metastatic behavior of this disease. Laminin subunit beta-3 …

Hypoxia-inducible factors (HIFs) are α/β heterodimeric transcription factors modulating
cellular responses to the low oxygen condition. Among three HIF-α isoforms, HIF-3α is the …

Signal perception is a key function in regulating biological activities and adapting to
changing environments. Per-Arnt-Sim (PAS) domains are ubiquitous sensors found in …

Abstract Recently, N6-methyladenosine (m6A) has aroused widespread discussion in the
scientific community as a mode of RNA modification. m6A comprises writers, erasers, and …

An accumulation of evidence indicates that long noncoding RNAs are involved in the
tumorigenesis and progression of pancreatic cancer (PC). In this study, we investigated the …

Hypoxia is a common phenomenon in most malignant tumors, especially in pancreatic
cancer (PC). Hypoxia is the result of unlimited tumor growth and plays an active role in …

Pheochromocytomas and paragangliomas (PPGLs) provide some of the clearest genetic
evidence for the critical role of metabolism in the tumorigenesis process. Approximately 40 …

Cancer cells reprogram their metabolism to meet biosynthetic needs and to adapt to various
microenvironments. Accelerated glycolysis offers proliferative benefits for malignant cells by …