Causes and consequences of polycystic ovary syndrome: insights from Mendelian randomization
T Zhu, MO Goodarzi - The Journal of Clinical Endocrinology & …, 2022 - academic.oup.com
Context Although polycystic ovary syndrome (PCOS) is the most common endocrinopathy
affecting women of reproductive age, risk factors that may cause the syndrome are poorly …
affecting women of reproductive age, risk factors that may cause the syndrome are poorly …
Genetic and Epigenetic Landscape for Drug Development in Polycystic Ovary Syndrome
Y Chen, G Wang, J Chen, C Wang, X Dong… - Endocrine …, 2024 - academic.oup.com
The treatment of polycystic ovary syndrome (PCOS) faces challenges as all known
treatments are merely symptomatic. The US Food and Drug Administration (FDA) has not …
treatments are merely symptomatic. The US Food and Drug Administration (FDA) has not …
PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome
L Mu, Z Ye, J Hu, Y Zhang, K Chen, H Sun, R Li… - …, 2023 - thelancet.com
Background Polycystic ovary syndrome (PCOS) is one of the most common diseases with
the coexistence of reproductive malfunction and metabolic disorders. Previous studies have …
the coexistence of reproductive malfunction and metabolic disorders. Previous studies have …
Raman spectroscopy of follicular fluid and plasma with machine-learning algorithms for polycystic ovary syndrome screening
X Zhang, B Liang, J Zhang, X Hao, X Xu… - Molecular and cellular …, 2021 - Elsevier
Polycystic ovary syndrome (PCOS) is the main cause of anovulatory infertility and affects
women throughout their lives. The specific diagnostic method is still under investigation. In …
women throughout their lives. The specific diagnostic method is still under investigation. In …
Insights into genetic variants associated with NASH-fibrosis from metabolite profiling
Several genetic discoveries robustly implicate five single-nucleotide variants in the
progression of non-alcoholic fatty liver disease to non-alcoholic steatohepatitis and fibrosis …
progression of non-alcoholic fatty liver disease to non-alcoholic steatohepatitis and fibrosis …
Metabolomics: population epidemiology and concordance in Australian children aged 11–12 years and their parents
Objectives Nuclear magnetic resonance (NMR) metabolomics is high throughput and cost-
effective, with the potential to improve the understanding of disease and risk. We examine …
effective, with the potential to improve the understanding of disease and risk. We examine …
Depletion of gut microbiota influents glucose metabolism and hyperandrogenism traits of mice with PCOS induced by letrozole
Y Li, Y Zhu, D Li, W Liu, Y Zhang, W Liu… - Frontiers in …, 2023 - frontiersin.org
Background Polycystic ovary syndrome (PCOS) is a multifaceted disorder that impacts
metabolism, reproduction, as well as endocrine function, characterized by excessive levels …
metabolism, reproduction, as well as endocrine function, characterized by excessive levels …
Non-targeted profiling of circulating microRNAs in women with polycystic ovary syndrome (PCOS): effects of obesity and sex hormones
M Murri, M Insenser, E Fernández-Durán… - Metabolism, 2018 - Elsevier
Purpose Circulating micro-ribonucleic acids (miRNAs) are small noncoding RNA molecules
that influence gene transcription. We conducted the present profiling study to characterize …
that influence gene transcription. We conducted the present profiling study to characterize …
Application of metabolomics for unveiling the therapeutic role of traditional Chinese medicine in metabolic diseases
G Wu, W Zhang, H Li - Journal of Ethnopharmacology, 2019 - Elsevier
Ethnopharmacological relevance Traditional medicine has been practiced for thousands of
years in China and some Asian countries. Traditional Chinese Medicine (TCM) is …
years in China and some Asian countries. Traditional Chinese Medicine (TCM) is …
Distinct metabolic signatures in blood plasma of bisphenol A–exposed women with polycystic ovarian syndrome
Polycystic ovarian syndrome (PCOS) is a complicated endocrinopathy with an unclear
etiology that afflicts fertility status in women. Although the underlying causes and …
etiology that afflicts fertility status in women. Although the underlying causes and …