Causes and consequences of polycystic ovary syndrome: insights from Mendelian randomization

T Zhu, MO Goodarzi - The Journal of Clinical Endocrinology & …, 2022 - academic.oup.com
Context Although polycystic ovary syndrome (PCOS) is the most common endocrinopathy
affecting women of reproductive age, risk factors that may cause the syndrome are poorly …

Genetic and Epigenetic Landscape for Drug Development in Polycystic Ovary Syndrome

Y Chen, G Wang, J Chen, C Wang, X Dong… - Endocrine …, 2024 - academic.oup.com
The treatment of polycystic ovary syndrome (PCOS) faces challenges as all known
treatments are merely symptomatic. The US Food and Drug Administration (FDA) has not …

PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome

L Mu, Z Ye, J Hu, Y Zhang, K Chen, H Sun, R Li… - …, 2023 - thelancet.com
Background Polycystic ovary syndrome (PCOS) is one of the most common diseases with
the coexistence of reproductive malfunction and metabolic disorders. Previous studies have …

Raman spectroscopy of follicular fluid and plasma with machine-learning algorithms for polycystic ovary syndrome screening

X Zhang, B Liang, J Zhang, X Hao, X Xu… - Molecular and cellular …, 2021 - Elsevier
Polycystic ovary syndrome (PCOS) is the main cause of anovulatory infertility and affects
women throughout their lives. The specific diagnostic method is still under investigation. In …

Insights into genetic variants associated with NASH-fibrosis from metabolite profiling

JP Mann, M Pietzner, LB Wittemans… - Human molecular …, 2020 - academic.oup.com
Several genetic discoveries robustly implicate five single-nucleotide variants in the
progression of non-alcoholic fatty liver disease to non-alcoholic steatohepatitis and fibrosis …

Metabolomics: population epidemiology and concordance in Australian children aged 11–12 years and their parents

S Ellul, M Wake, SA Clifford, K Lange, P Würtz… - BMJ open, 2019 - bmjopen.bmj.com
Objectives Nuclear magnetic resonance (NMR) metabolomics is high throughput and cost-
effective, with the potential to improve the understanding of disease and risk. We examine …

Depletion of gut microbiota influents glucose metabolism and hyperandrogenism traits of mice with PCOS induced by letrozole

Y Li, Y Zhu, D Li, W Liu, Y Zhang, W Liu… - Frontiers in …, 2023 - frontiersin.org
Background Polycystic ovary syndrome (PCOS) is a multifaceted disorder that impacts
metabolism, reproduction, as well as endocrine function, characterized by excessive levels …

Non-targeted profiling of circulating microRNAs in women with polycystic ovary syndrome (PCOS): effects of obesity and sex hormones

M Murri, M Insenser, E Fernández-Durán… - Metabolism, 2018 - Elsevier
Purpose Circulating micro-ribonucleic acids (miRNAs) are small noncoding RNA molecules
that influence gene transcription. We conducted the present profiling study to characterize …

Application of metabolomics for unveiling the therapeutic role of traditional Chinese medicine in metabolic diseases

G Wu, W Zhang, H Li - Journal of Ethnopharmacology, 2019 - Elsevier
Ethnopharmacological relevance Traditional medicine has been practiced for thousands of
years in China and some Asian countries. Traditional Chinese Medicine (TCM) is …

Distinct metabolic signatures in blood plasma of bisphenol A–exposed women with polycystic ovarian syndrome

NB Prabhu, S Vasishta, SK Bhat, MB Joshi… - … Science and Pollution …, 2023 - Springer
Polycystic ovarian syndrome (PCOS) is a complicated endocrinopathy with an unclear
etiology that afflicts fertility status in women. Although the underlying causes and …