Spine dynamics in the brain, mental disorders and artificial neural networks
In the brain, most synapses are formed on minute protrusions known as dendritic spines.
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …
Sex differences and the neurobiology of affective disorders
DR Rubinow, PJ Schmidt - Neuropsychopharmacology, 2019 - nature.com
Observations of the disproportionate incidence of depression in women compared with men
have long preceded the recent explosion of interest in sex differences. Nonetheless, the …
have long preceded the recent explosion of interest in sex differences. Nonetheless, the …
Structural plasticity of the hippocampus in response to estrogens in female rodents
It is well established that estrogens affect neuroplasticity in a number of brain regions. In
particular, estrogens modulate and mediate spine and synapse formation as well as …
particular, estrogens modulate and mediate spine and synapse formation as well as …
Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents
Ample evidence has demonstrated that sex steroid hormones, such as the potent estrogen
17β-estradiol (E2), affect hippocampal morphology, plasticity, and memory in male and …
17β-estradiol (E2), affect hippocampal morphology, plasticity, and memory in male and …
Sex differences in hippocampal function
Sex differences in the function of the hippocampus have been observed in numerous
mammalian species. However, the magnitude, extent, and specificity of these differences are …
mammalian species. However, the magnitude, extent, and specificity of these differences are …
Why estrogens matter for behavior and brain health
Abstract The National Institutes of Health (NIH) has required the inclusion of women in
clinical studies since 1993, which has enhanced our understanding of how biological sex …
clinical studies since 1993, which has enhanced our understanding of how biological sex …
Molecular mechanisms underlying the memory-enhancing effects of estradiol
KM Frick - Hormones and behavior, 2015 - Elsevier
This article is part of a Special Issue “Estradiol and cognition”. Since the publication of the
1998 special issue of Hormones and Behavior on estrogens and cognition, substantial …
1998 special issue of Hormones and Behavior on estrogens and cognition, substantial …
Estradiol-mediated spine changes in the dorsal hippocampus and medial prefrontal cortex of ovariectomized female mice depend on ERK and mTOR activation in the …
Dendritic spine plasticity underlies the formation and maintenance of memories. Both natural
fluctuations and systemic administration of 17β-estradiol (E2) alter spine density in the …
fluctuations and systemic administration of 17β-estradiol (E2) alter spine density in the …
AMPA-silent synapses in brain development and pathology
Synapses are constantly generated at a high rate in the developing, prepubescent brain.
Newly generated glutamatergic synapses lack functional AMPA receptor-mediated …
Newly generated glutamatergic synapses lack functional AMPA receptor-mediated …
Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling
The 5-HT2A serotonin receptor is the most abundant serotonin receptor subtype in the
cortex and is predominantly expressed in pyramidal neurons. The 5-HT2A receptor is a …
cortex and is predominantly expressed in pyramidal neurons. The 5-HT2A receptor is a …