The influence of microbiota on ferroptosis in intestinal diseases

T Yao, L Li - Gut Microbes, 2023 - Taylor & Francis
Ferroptosis is a distinctive form of iron-dependent necrotic cell death, characterized by
excessive lipid peroxidation on cellular membranes and compromised cellular antioxidant …

[HTML][HTML] The Gum–Gut Axis: Periodontitis and the Risk of Gastrointestinal Cancers

G Baima, DG Ribaldone, F Romano, M Aimetti… - Cancers, 2023 - mdpi.com
Simple Summary Periodontitis, a chronic inflammatory disease of the gums, and the oral
microbiome have been recently implicated in the development of various cancers. Due to …

[HTML][HTML] Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics

JB Simpson, ME Walker, JJ Sekela, SM Ivey… - Cell Host & Microbe, 2024 - cell.com
Hormones and neurotransmitters are essential to homeostasis, and their disruptions are
connected to diseases ranging from cancer to anxiety. The differential reactivation of …

[HTML][HTML] Irinotecan cause the side effects on development and adult physiology, and induces intestinal damage via innate immune response and oxidative damage in …

J He, S Han, Y Wang, Q Kang, X Wang, Y Su… - Biomedicine & …, 2023 - Elsevier
Chemotherapy leads to significant side effects in patients, especially in the gut, resulting in
various clinical manifestations and enhanced economic pressure. Until now, many of the …

Gut microbiota in cancer: insights on microbial metabolites and therapeutic strategies

Y Chen, X Wang, Y Ye, Q Ren - Medical Oncology, 2023 - Springer
In recent years, the role of gut microbiota in cancer treatment has attracted substantial
attention. It is now well established that gut microbiota and its metabolites significantly …

[HTML][HTML] Comprehensive analyses identify potential biomarkers for encephalitis in HIV infection

S Wang, X Ding, Z Li, F Rao, H Xu, J Lu, X Ma… - Scientific Reports, 2023 - nature.com
Human immunodeficiency virus encephalitis (HIVE) is a severe neurological complication
after HIV infection. Evidence shows that genetic factors play an important role in HIVE. The …

[HTML][HTML] Unraveling the role of medicinal plants and Gut microbiota in colon cancer: Towards microbiota-based strategies for prevention and treatment

A Vignesh, TC Amal, S Selvakumar, K Vasanth - Health Sciences Review, 2023 - Elsevier
Colon cancer remains one of the leading causes of morbidity and mortality worldwide. Given
its widespread prevalence, the identification of new anticancer drugs is crucial. Medicinal …

Ginsenoside Rh4 alleviates gastrointestinal mucositis and enhances chemotherapy efficacy through modulating gut microbiota

X Bai, J Deng, Z Duan, R Fu, C Zhu, D Fan - Phytomedicine, 2024 - Elsevier
Background Gastrointestinal mucositis stands as one of the most severe side effects of
irinotecan (CPT-11). however, only palliative treatment is available at present. Therefore …

Discovery of a botanical compound as a broad-spectrum inhibitor against gut microbial β-glucuronidases from the Tibetan medicine Rhodiola crenulata

L Chen, XD Hou, GH Zhu, J Huang, ZB Guo… - International Journal of …, 2024 - Elsevier
Gut microbial β-glucuronidases (gmβ-GUS) played crucial roles in regulating a variety of
endogenous substances and xenobiotics on the circulating level, thus had been recognized …

Gut Microbiota—Adversary or Ally? Its Role and Significance in Colorectal Cancer Pathogenesis, Progression, and Treatment

K Chawrylak, M Leśniewska, K Mielniczek, K Sędłak… - Cancers, 2024 - mdpi.com
In 2022, colorectal cancer (CRC) was the third most prevalent malignancy worldwide. The
therapeutic approach for CRC typically involves a multimodal regimen. The human gut …