The global spread of antibiotic resistance genes (ARGs) has wreaked havoc with the
treatment efficiency of antibiotics and, ultimately, anti-microbial chemotherapy, and has been …

Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic
microorganisms. Because of the complex and long‐term abnormal conditions, osteomyelitis …

Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Lipopolysaccharide is a virulence factor of gram‐negative bacteria with a crucial importance
to the bacterial surface integrity. From the host's perspective, lipopolysaccharide plays a role …

Lipopolysaccharide (LPS) resides in the outer membrane of Gram-negative bacteria where it
is responsible for barrier function,. LPS can cause death as a result of septic shock, and its …

Since the advent of penicillin, humans have known about and explored the phenomenon of
bacterial inhibition via antibiotics. However, with changes in the global environment and the …

It has been nearly 50 years since the golden age of antibiotic discovery (1945–1975) ended;
yet, we still struggle to identify novel drug targets and to deliver new chemical classes of …

The usage of quaternary ammonium compounds (QACs) as disinfectants has increased
dramatically since the outbreak of COVID-19 pandemic, leading to potentially accelerated …

Plant byproducts and waste present enormous environmental challenges and an
opportunity for valorization and industrial application. Due to consumer demands for natural …

Gram-negative bacteria pose a major threat to human health in an era fraught with multi-
drug resistant bacterial infections. Despite extensive drug discovery campaigns over the …