Radiomics, the high-throughput mining of quantitative image features from standard-of-care
medical imaging that enables data to be extracted and applied within clinical-decision …

Photodynamic therapy (PDT) is a minimally invasive treatment that destroys target cells in
the presence of oxygen when light irradiates a photosensitizer, generating highly reactive …

Deep learning methods for digital pathology analysis are an effective way to address
multiple clinical questions, from diagnosis to prediction of treatment outcomes. These …

Many vaccines induce protective immunity via antibodies. Systems biology approaches
have been used to determine signatures that can be used to predict vaccine-induced …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Combined analyses of molecular data, such as DNA copy-number alteration, mRNA and
protein expression, point to biological functions and molecular pathways being deregulated …

Cancer cells possess traits reminiscent of those ascribed to normal stem cells. It is unclear,
however, whether these phenotypic similarities reflect the activity of common molecular …

Motivation: High-throughput data is providing a comprehensive view of the molecular
changes in cancer tissues. New technologies allow for the simultaneous genome-wide …

Nuclear factor κB (NF-κB) transcription factors have a key role in many physiological
processes such as innate and adaptive immune responses, cell proliferation, cell death, and …

Human genes contain a dense array of diverse cis-acting elements that make up a code
required for the expression of correctly spliced mRNAs. Alternative splicing generates a …