Progress towards the development of a universal influenza vaccine
Influenza viruses are responsible for millions of cases globally and significantly threaten
public health. Since pandemic and zoonotic influenza viruses have emerged in the last 20 …
public health. Since pandemic and zoonotic influenza viruses have emerged in the last 20 …
Technological microbiology: development and applications
LC Vitorino, LA Bessa - Frontiers in Microbiology, 2017 - frontiersin.org
Over thousands of years, modernization could be predicted for the use of microorganisms in
the production of foods and beverages. However, the current accelerated pace of new food …
the production of foods and beverages. However, the current accelerated pace of new food …
Pulmonary surfactant–biomimetic nanoparticles potentiate heterosubtypic influenza immunity
INTRODUCTION Current influenza vaccines must be refreshed annually to address constant
mutations of viral hemagglutinin (HA) and neuraminidase (NA) genes because the vaccines …
mutations of viral hemagglutinin (HA) and neuraminidase (NA) genes because the vaccines …
Generation of a live attenuated influenza A vaccine by proteolysis targeting
The usefulness of live attenuated virus vaccines has been limited by suboptimal
immunogenicity, safety concerns or cumbersome manufacturing processes and techniques …
immunogenicity, safety concerns or cumbersome manufacturing processes and techniques …
Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design
In conventional attenuated viral vaccines, immunogenicity is often suboptimal. Here we
present a systematic approach for vaccine development that eliminates interferon (IFN) …
present a systematic approach for vaccine development that eliminates interferon (IFN) …
Generation of DelNS1 influenza viruses: a strategy for optimizing live attenuated influenza vaccines
ABSTRACT Nonstructural protein 1 (NS1) of influenza virus is a key virulence element with
multifunctional roles in virus replication and a potent antagonist of host immune response …
multifunctional roles in virus replication and a potent antagonist of host immune response …
Attenuated influenza virions expressing the SARS-CoV-2 receptor-binding domain induce neutralizing antibodies in mice
An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here,
we describe an influenza virus-based vaccine for SARS-CoV-2. We incorporated a …
we describe an influenza virus-based vaccine for SARS-CoV-2. We incorporated a …
Improving immunological insights into the ferret model of human viral infectious disease
J Wong, D Layton, AK Wheatley… - Influenza and Other …, 2019 - Wiley Online Library
Ferrets are a well‐established model for studying both the pathogenesis and transmission of
human respiratory viruses and evaluation of antiviral vaccines. Advanced immunological …
human respiratory viruses and evaluation of antiviral vaccines. Advanced immunological …
The intersection of age and influenza severity: Utility of ferrets for dissecting the age-dependent immune responses and relevance to age-specific vaccine …
M Rioux, ME Francis, CL Swan, A Ge, A Kroeker… - Viruses, 2021 - mdpi.com
Many factors impact the host response to influenza virus infection and vaccination. Ferrets
have been an indispensable reagent for influenza virus research for almost one hundred …
have been an indispensable reagent for influenza virus research for almost one hundred …
Crossprotection induced by virus-like particles containing influenza dual-hemagglutinin and M2 ectodomain
J Mao, GD Eom, KW Yoon, MJ Kim, KB Chu… - …, 2024 - Taylor & Francis
Aims: To develop an effective universal vaccine against antigenically different influenza
viruses. Materials & methods: We generated influenza virus-like particles (VLPs) expressing …
viruses. Materials & methods: We generated influenza virus-like particles (VLPs) expressing …