Autophagy and the insulin-like growth factor (IGF) system in colonic cells: implications for colorectal neoplasia

A Kasprzak - International journal of molecular sciences, 2023 - mdpi.com
Colorectal cancer (CRC) is one of the most common human malignancies worldwide. Along
with apoptosis and inflammation, autophagy is one of three important mechanisms in CRC …

Cell-free dna in the pathogenesis and therapy of non-infectious inflammations and tumors

G Műzes, B Bohusné Barta, O Szabó, V Horgas… - Biomedicines, 2022 - mdpi.com
The basic function of the immune system is the protection of the host against infections,
along with the preservation of the individual antigenic identity. The process of self-tolerance …

Autoimmunity and Carcinogenesis: Their Relationship under the Umbrella of Autophagy

G Műzes, F Sipos - Biomedicines, 2023 - mdpi.com
The immune system and autophagy share a functional relationship. Both innate and
adaptive immune responses involve autophagy and, depending on the disease's origin and …

[HTML][HTML] Interconnection of CD133 Stem Cell Marker with Autophagy and Apoptosis in Colorectal Cancer

F Sipos, G Műzes - International Journal of Molecular Sciences, 2024 - mdpi.com
CD133 protein expression is observable in differentiated cells, stem cells, and progenitor
cells within normal tissues, as well as in tumor tissues, including colorectal cancer cells. The …

Cancer stem cell relationship with pro-tumoral inflammatory microenvironment

F Sipos, G Műzes - Biomedicines, 2023 - mdpi.com
Inflammatory processes and cancer stem cells (CSCs) are increasingly recognized as
factors in the development of tumors. Emerging evidence indicates that CSCs are …

Notch1 hyperactivity drives ubiquitination of NOX2 and dysfunction of CD8+ regulatory T cells in patients with systemic lupus erythematosus

Z Yuan, M Liu, L Zhang, L Jia, S Hao, D Su… - …, 2024 - academic.oup.com
Objectives Patients with systemic lupus erythematosus (SLE) display heightened immune
activation and elevated IgG autoantibody levels, indicating compromised regulatory T cell …

Insights from a Computational-Based Approach for Analyzing Autophagy Genes across Human Cancers

AG Murillo Carrasco, G Giovanini, AF Ramos… - Genes, 2023 - mdpi.com
In the last decade, there has been a boost in autophagy reports due to its role in cancer
progression and its association with tumor resistance to treatment. Despite this, many …

[PDF][PDF] The effects of indigenous South African plant extracts (cotyledon c. orbiculata and tulbaghia. violacea) on triple negative breast cancer cells

M Alaouna - 2024 - wiredspace.wits.ac.za
This dissertation explored the potential therapeutic applications of water and methanol
extracts of C. orbiculata and Tulbaghia violacea, indigenous to Southern Africa, targeting …

Molekulární mechanismy účinků cfDNA

N Hříbková - 2023 - dspace.cuni.cz
Biologická role volné cirkulující DNA je v současné době zkoumána především z hlediska
etiologie autoimunitních stavů a rakovinového onemocnění. Ukazuje se, že úloha cfDNA …