It is reported that approximately 40 million people are suffering from dementia, globally.
Dementia is a group of symptoms that affect neurons and cause some mental disorders …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence
of approximately 2 percent. A pattern of familial aggregation has been documented for the …

Lewy bodies (LBs) are hallmark lesions of degenerating neurons in the brains of patients
with Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Recently, a point …

Abstract α-Synuclein (α-Syn) is a 14 kDa protein of unknown function that has been
implicated in the pathophysiology of Parkinson's disease (PD). Here, we show that α-Syn …

A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

An increasing number of cases where amyloids of different proteins are found in the same
patient are being reported. This observation complicates diagnosis and clinical intervention …

Synuclein proteins are produced, in vertebrates, by three genes. They share structural
resemblance to apolipoproteins, but are abundant in the neuronal cytosol and present in …

Recently, α‐synuclein was shown to be a structural component of the filaments in Lewy
bodies (LBs) of Parkinson's disease (PD), dementia with LBs (DLB) as well as the LB variant …

A unifying feature of many neurodegenerative disorders is the accumulation of
polyubiquitinated protein inclusions in dystrophic neurons, eg containing α-synuclein, which …