Multiple aspects of neuronal physiology crucially depend on two cellular pathways,
autophagy and endocytosis. During endocytosis, extracellular components either unbound …

Studies on extracellular vesicles have increased in recent years. The multi-dimensional
nature of their roles in cellular homeostasis, cell-to-cell and tissue-to-tissue communication …

Extracellular vesicles (EVs) are cell-secreted particles with broad potential to treat tissue
injuries by delivering cargo to program target cells. However, improving the yield of …

Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer in Sub-Saharan
African countries, including South Africa (SA). Given the limitations in current HCC …

Stimulus transduction in cilia of olfactory sensory neurons is mediated by odorant receptors,
Gαolf, adenylate cyclase-3, cyclic nucleotide-gated and chloride ion channels. Mechanisms …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

Synapses maintain their molecular composition, plasticity and function through the
concerted action of protein synthesis and removal. The complex and polarized neuronal …

Studies on the pathogen–host interaction are crucial for the understanding of the
mechanisms involved in the establishment, maintenance, and spread of infection. In recent …

Automated electron microscopy methods produce a large number of serial sections that can
be stacked to reconstruct a three-dimensional (3D) sample of brain tissue. The visualization …

The living body is composed of innumerable fine and complex structures. Although these
structures have been studied in the past, a vast amount of information pertaining to them still …