The tumour suppressor gene TP53 is the most frequently mutated gene in cancer. Wild-type
p53 can suppress tumour development by multiple pathways. However, mutation of TP53 …

Background Cells have evolved balanced mechanisms to protect themselves by initiating a
specific response to a variety of stress. The TP53 gene, encoding P53 protein, is one of the …

p53 is an important tumor suppressor gene, which is stimulated by cellular stress like
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …

The TP53 tumor suppressor gene is mutated in many human tumors, including common
types of cancer such as colon and ovarian cancer. This illustrates the key role of p53 as …

Simple Summary The tumor suppressor protein p53 is frequently mutated in human cancers,
and its reactivation represents an encouraging hope for precision anticancer therapy …

Survival of patients with muscle-invasive bladder cancer is poor and new therapies are
needed. Currently, none of the targeted agents that are approved for cancer therapy have …

Forty-eight analogues of CP-31398, an antitumor agent modulated the mutant p53 gene
were synthesized and their cytotoxicities against four cancer cell lines with different p-53 …

The tumor suppressor protein p53 is often called “the genome guardian” and controls the
cell cycle and the integrity of DNA, as well as other important cellular functions. Its main …

The wild-type protein p53 plays a key role in preventing the formation of neoplasms by
controlling cell growth. However, in more than a half of all cancers, the TP53 gene has …

Motesanib (AMG 706) is a small organic molecule that acts as a multi-targeted tyrosine
kinase inhibitor of VEGF, PDGF and stem cell factor receptor. It exhibits a potent antitumor …