Treatment-refractory giardiasis: challenges and solutions

M Lalle, K Hanevik - Infection and drug resistance, 2018 - Taylor & Francis
Giardia is the commonest parasitic diarrheal pathogen affecting humans and a frequent
cause of waterborne/foodborne parasitic diseases worldwide. Prevalence of giardiasis is …

Drug Resistance in the Microaerophilic Parasite Giardia lamblia

D Leitsch - Current tropical medicine reports, 2015 - Springer
The microaerophilic parasite Giardia lamblia is a causative agent of dysentery affecting
hundreds of millions of people around the globe every year. The symptoms of the disease …

Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs

D Nillius, J Müller, N Müller - Journal of antimicrobial …, 2011 - academic.oup.com
Abstract Objectives The protozoan parasite Giardia lamblia causes the intestinal disease
giardiasis, which may lead to acute and chronic diarrhoea in humans and various animal …

Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum

KM Hennessey, IC Rogiers, HW Shih… - PLoS neglected …, 2018 - journals.plos.org
There is need for a more efficient cell-based assay amenable to high-throughput drug
screening against Giardia lamblia. Here, we report the development of a screening method …

A Rapid, High-Throughput Viability Assay for Blastocystis spp. Reveals Metronidazole Resistance and Extensive Subtype-Dependent Variations in Drug …

H Mirza, JDW Teo, J Upcroft… - Antimicrobial agents and …, 2011 - Am Soc Microbiol
Blastocystis is an emerging protistan parasite of controversial pathogenesis. Although
metronidazole (Mz) is standard therapy for Blastocystis infections, there have been …

Giardia disrupts the arrangement of tight, adherens and desmosomal junction proteins of intestinal cells

C Maia-Brigagão, JA Morgado-Díaz… - Parasitology international, 2012 - Elsevier
Giardia duodenalis is a parasitic protozoan that causes diarrhea and other symptoms which
together constitute a disease known as giardiasis. Although the disease has been well …

Albendazole induces oxidative stress and DNA damage in the parasitic protozoan Giardia duodenalis

R Martínez-Espinosa, R Argüello-García… - Frontiers in …, 2015 - frontiersin.org
The control of Giardia duodenalis infections is carried out mainly by drugs, among these
albendazole (ABZ) is commonly used. Although the cytotoxic effect of ABZ usually involves …

High-fat diet increases the severity of Giardia infection in association with low-grade inflammation and gut microbiota dysbiosis

T Allain, E Fekete, O Sosnowski… - Scientific Reports, 2021 - nature.com
Exogenous factors that may influence the pathophysiology of Giardia infection remain
incompletely understood. We have investigated the role of dietary fat in the pathogenesis of …

Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment

BS Erikstein, HR Hagland, J Nikolaisen… - Journal of cellular …, 2010 - Wiley Online Library
Mitochondrial bioenergetics and reactive oxygen species (ROS) often play important roles in
cellular stress mechanisms. In this study we investigated how these factors are involved in …

Flavonoids from Piper Species as Promising Antiprotozoal Agents against Giardia intestinalis: Structure-Activity Relationship and Drug-Likeness Studies

JC Ticona, P Bilbao-Ramos, Á Amesty, N Flores… - Pharmaceuticals, 2022 - mdpi.com
Diarrhea diseases caused by the intestinal protozoan parasite Giardia intestinalis are a
major global health burden. Moreover, there is an ongoing need for novel anti-Giardia drugs …